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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22349

FusionGeneSummary for MPHOSPH8_MPHOSPH8

check button Fusion gene summary
Fusion gene informationFusion gene name: MPHOSPH8_MPHOSPH8
Fusion gene ID: 22349
HgeneTgene
Gene symbol

MPHOSPH8

MPHOSPH8

Gene ID

54737

54737

Gene nameM-phase phosphoprotein 8M-phase phosphoprotein 8
SynonymsHSMPP8|TWA3|mpp8HSMPP8|TWA3|mpp8
Cytomap

13q12.11

13q12.11

Type of geneprotein-codingprotein-coding
DescriptionM-phase phosphoprotein 8M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPMM-phase phosphoprotein 8M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPM
Modification date2018051920180519
UniProtAcc

Q99549

Q99549

Ensembl transtripts involved in fusion geneENST00000414242, ENST00000361479, 
ENST00000496525, 		ENST00000414242, 
ENST00000361479, ENST00000496525, 
Fusion gene scores* DoF score3 X 7 X 2=428 X 12 X 3=288
# samples 713
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/288*10)=-1.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPHOSPH8 [Title/Abstract] AND MPHOSPH8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI857307MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
ChiTaRS3.1BI858901MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
ChiTaRS3.1BU736580MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
ChiTaRS3.1BM717590MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
ChiTaRS3.1BM674866MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000414242ENST00000414242MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
In-frameENST00000414242ENST00000361479MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
5CDS-intronENST00000414242ENST00000496525MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
In-frameENST00000361479ENST00000414242MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
In-frameENST00000361479ENST00000361479MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
5CDS-intronENST00000361479ENST00000496525MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
intron-3CDSENST00000496525ENST00000414242MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
intron-3CDSENST00000496525ENST00000361479MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
intron-intronENST00000496525ENST00000496525MPHOSPH8chr13

20220850

-MPHOSPH8chr13

20222591

-
Frame-shiftENST00000414242ENST00000414242MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
Frame-shiftENST00000414242ENST00000361479MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
5CDS-intronENST00000414242ENST00000496525MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
Frame-shiftENST00000361479ENST00000414242MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
Frame-shiftENST00000361479ENST00000361479MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
5CDS-intronENST00000361479ENST00000496525MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
intron-3CDSENST00000496525ENST00000414242MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
intron-3CDSENST00000496525ENST00000361479MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
intron-intronENST00000496525ENST00000496525MPHOSPH8chr13

20224401

+MPHOSPH8chr13

20216252

+
intron-intronENST00000414242ENST00000414242MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
intron-3UTRENST00000414242ENST00000361479MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
intron-intronENST00000414242ENST00000496525MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
3UTR-intronENST00000361479ENST00000414242MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
3UTR-3UTRENST00000361479ENST00000361479MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
3UTR-intronENST00000361479ENST00000496525MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
intron-intronENST00000496525ENST00000414242MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
intron-3UTRENST00000496525ENST00000361479MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
intron-intronENST00000496525ENST00000496525MPHOSPH8chr13

20246399

-MPHOSPH8chr13

20246987

-
intron-intronENST00000414242ENST00000414242MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
intron-3UTRENST00000414242ENST00000361479MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
intron-intronENST00000414242ENST00000496525MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
3UTR-intronENST00000361479ENST00000414242MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
3UTR-3UTRENST00000361479ENST00000361479MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
3UTR-intronENST00000361479ENST00000496525MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
intron-intronENST00000496525ENST00000414242MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
intron-3UTRENST00000496525ENST00000361479MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
intron-intronENST00000496525ENST00000496525MPHOSPH8chr13

20246954

+MPHOSPH8chr13

20246503

+
intron-intronENST00000414242ENST00000414242MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
intron-3UTRENST00000414242ENST00000361479MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
intron-intronENST00000414242ENST00000496525MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
3UTR-intronENST00000361479ENST00000414242MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
3UTR-3UTRENST00000361479ENST00000361479MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
3UTR-intronENST00000361479ENST00000496525MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
intron-intronENST00000496525ENST00000414242MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
intron-3UTRENST00000496525ENST00000361479MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-
intron-intronENST00000496525ENST00000496525MPHOSPH8chr13

20246503

-MPHOSPH8chr13

20246954

-

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FusionProtFeatures for MPHOSPH8_MPHOSPH8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPHOSPH8

Q99549

MPHOSPH8

Q99549

Heterochromatin component that specifically recognizesand binds methylated 'Lys-9' of histone H3 (H3K9me) and promotesrecruitment of proteins that mediate epigenetic repression(PubMed:20871592, PubMed:26022416). Mediates recruitment of theHUSH complex to H3K9me3 sites: the HUSH complex is recruited togenomic loci rich in H3K9me3 and is probably required to maintaintranscriptional silencing by promoting recruitment of SETDB1, ahistone methyltransferase that mediates further deposition ofH3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNAmethylation by recruiting DNMT3A to target CpG sites; these can besituated within the coding region of the gene (PubMed:20871592).Mediates down-regulation of CDH1 expression (PubMed:20871592).{ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416}. Heterochromatin component that specifically recognizesand binds methylated 'Lys-9' of histone H3 (H3K9me) and promotesrecruitment of proteins that mediate epigenetic repression(PubMed:20871592, PubMed:26022416). Mediates recruitment of theHUSH complex to H3K9me3 sites: the HUSH complex is recruited togenomic loci rich in H3K9me3 and is probably required to maintaintranscriptional silencing by promoting recruitment of SETDB1, ahistone methyltransferase that mediates further deposition ofH3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNAmethylation by recruiting DNMT3A to target CpG sites; these can besituated within the coding region of the gene (PubMed:20871592).Mediates down-regulation of CDH1 expression (PubMed:20871592).{ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+014151_256-23861Compositional biasNote=Lys-rich
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+013151_256-34868Compositional biasNote=Lys-rich
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+01459_118-23861DomainChromo
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+01359_118-34868DomainChromo
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+01480_87-23861RegionHistone H3K9me3 binding
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+01380_87-34868RegionHistone H3K9me3 binding
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+014600_629-23861RepeatNote=ANK 1
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+014633_662-23861RepeatNote=ANK 2
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+014666_695-23861RepeatNote=ANK 3
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+014699_728-23861RepeatNote=ANK 4
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+013600_629-34868RepeatNote=ANK 1
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+013633_662-34868RepeatNote=ANK 2
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+013666_695-34868RepeatNote=ANK 3
TgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+013699_728-34868RepeatNote=ANK 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+114151_256-23861Compositional biasNote=Lys-rich
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+113151_256-34868Compositional biasNote=Lys-rich
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+11459_118-23861DomainChromo
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+11359_118-34868DomainChromo
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+11480_87-23861RegionHistone H3K9me3 binding
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+11380_87-34868RegionHistone H3K9me3 binding
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+114600_629-23861RepeatNote=ANK 1
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+114633_662-23861RepeatNote=ANK 2
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+114666_695-23861RepeatNote=ANK 3
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000361479+114699_728-23861RepeatNote=ANK 4
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+113600_629-34868RepeatNote=ANK 1
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+113633_662-34868RepeatNote=ANK 2
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+113666_695-34868RepeatNote=ANK 3
HgeneMPHOSPH8chr13:20220850chr13:20222591ENST00000414242+113699_728-34868RepeatNote=ANK 4


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FusionGeneSequence for MPHOSPH8_MPHOSPH8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPHOSPH8_MPHOSPH8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPHOSPH8RANBP9, SH3BP4, DNMT3A, EHMT1, MPHOSPH8, MTRNR2L1, ENO1, MOV10, NXF1, BMI1, ZNF597, IFI16, HIST1H2BG, ERCC6, HCFC1, ILF3, NOP2, NUMA1, RPL24, MRPS12, RPS11, SAFB, UBTF, ZNF121, BRPF1, TRRAP, SAFB2, MATR3, TBC1D4, KHDRBS1, HECW1, ANKLE2, FAM208A, RPL36, FBXL6, ZNF638, MRPL18, PPHLN1, YIPF5, FAM208B, ZNF770, PHIP, TMEM33, IMP3, DDX28, ESYT2, NCOA5, DYNLRB1, UTP23, FAM195A, SPIRE2, USMG5, ZNF845, MB21D1, TSR3, RPP25L, LRWD1, SIRT1, ZEB1, HIST1H3A, ESAMMPHOSPH8RANBP9, SH3BP4, DNMT3A, EHMT1, MPHOSPH8, MTRNR2L1, ENO1, MOV10, NXF1, BMI1, ZNF597, IFI16, HIST1H2BG, ERCC6, HCFC1, ILF3, NOP2, NUMA1, RPL24, MRPS12, RPS11, SAFB, UBTF, ZNF121, BRPF1, TRRAP, SAFB2, MATR3, TBC1D4, KHDRBS1, HECW1, ANKLE2, FAM208A, RPL36, FBXL6, ZNF638, MRPL18, PPHLN1, YIPF5, FAM208B, ZNF770, PHIP, TMEM33, IMP3, DDX28, ESYT2, NCOA5, DYNLRB1, UTP23, FAM195A, SPIRE2, USMG5, ZNF845, MB21D1, TSR3, RPP25L, LRWD1, SIRT1, ZEB1, HIST1H3A, ESAM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPHOSPH8_MPHOSPH8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPHOSPH8_MPHOSPH8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource