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Fusion gene ID: 22335 |
FusionGeneSummary for MPDZ_LURAP1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPDZ_LURAP1L | Fusion gene ID: 22335 | Hgene | Tgene | Gene symbol | MPDZ | LURAP1L | Gene ID | 84708 | 286343 |
| Gene name | ligand of numb-protein X 1 | leucine rich adaptor protein 1 like | |
| Synonyms | LNX|MPDZ|PDZRN2 | C9orf150|HYST0841|LRAP35b|bA3L8.2 | |
| Cytomap | 4q12 | 9p23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr | leucine rich adaptor protein 1-likeleucine repeat adaptor protein 35b | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O75970 | Q8IV03 | |
| Ensembl transtripts involved in fusion gene | ENST00000319217, ENST00000541718, ENST00000381022, ENST00000541093, ENST00000538841, ENST00000536827, ENST00000447879, ENST00000381015, ENST00000546205, ENST00000540202, | ENST00000319264, ENST00000489107, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 2 X 3=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MPDZ [Title/Abstract] AND LURAP1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A150-01A | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000319217 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| 5CDS-intron | ENST00000319217 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| In-frame | ENST00000541718 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| 5CDS-intron | ENST00000541718 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| Frame-shift | ENST00000381022 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| 5CDS-intron | ENST00000381022 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| intron-3CDS | ENST00000541093 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| intron-intron | ENST00000541093 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| intron-3CDS | ENST00000538841 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| intron-intron | ENST00000538841 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| Frame-shift | ENST00000536827 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| 5CDS-intron | ENST00000536827 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| Frame-shift | ENST00000447879 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| 5CDS-intron | ENST00000447879 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| Frame-shift | ENST00000381015 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| 5CDS-intron | ENST00000381015 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| In-frame | ENST00000546205 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| 5CDS-intron | ENST00000546205 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| intron-3CDS | ENST00000540202 | ENST00000319264 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
| intron-intron | ENST00000540202 | ENST00000489107 | MPDZ | chr9 | 13247634 | - | LURAP1L | chr9 | 12821385 | + |
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FusionProtFeatures for MPDZ_LURAP1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPDZ | LURAP1L |