|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22308 |
FusionGeneSummary for MORF4L2_GNB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MORF4L2_GNB1 | Fusion gene ID: 22308 | Hgene | Tgene | Gene symbol | MORF4L2 | GNB1 | Gene ID | 9643 | 2782 |
| Gene name | mortality factor 4 like 2 | G protein subunit beta 1 | |
| Synonyms | MORFL2|MRGX | MRD42 | |
| Cytomap | Xq22.2 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGX | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1beta subunit, signal-transducing proteins GS/GIguanine nucleotide binding protein (G protein), beta polypeptide 1testicular tissue protein Li 72transducin beta chain 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q15014 | P62873 | |
| Ensembl transtripts involved in fusion gene | ENST00000360458, ENST00000422154, ENST00000451301, ENST00000433176, ENST00000423833, ENST00000441076, ENST00000492116, | ENST00000378609, ENST00000472614, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 17 X 20 X 9=3060 |
| # samples | 3 | 26 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(26/3060*10)=-3.55694812455156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MORF4L2 [Title/Abstract] AND GNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AV717096 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000360458 | ENST00000378609 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000360458 | ENST00000472614 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000422154 | ENST00000378609 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000422154 | ENST00000472614 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000451301 | ENST00000378609 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000451301 | ENST00000472614 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000433176 | ENST00000378609 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000433176 | ENST00000472614 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000423833 | ENST00000378609 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000423833 | ENST00000472614 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000441076 | ENST00000378609 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000441076 | ENST00000472614 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000492116 | ENST00000378609 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
| intron-intron | ENST00000492116 | ENST00000472614 | MORF4L2 | chrX | 102935090 | - | GNB1 | chr1 | 1778027 | + |
Top |
FusionProtFeatures for MORF4L2_GNB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MORF4L2 | GNB1 |