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Fusion gene ID: 22304 |
FusionGeneSummary for MORC3_PPP3R1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MORC3_PPP3R1 | Fusion gene ID: 22304 | Hgene | Tgene | Gene symbol | MORC3 | PPP3R1 | Gene ID | 23515 | 5534 |
| Gene name | MORC family CW-type zinc finger 3 | protein phosphatase 3 regulatory subunit B, alpha | |
| Synonyms | NXP2|ZCW5|ZCWCC3 | CALNB1|CNB|CNB1 | |
| Cytomap | 21q22.12 | 2p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3 | calcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q14149 | P63098 | |
| Ensembl transtripts involved in fusion gene | ENST00000400485, ENST00000487909, | ENST00000234310, ENST00000409752, ENST00000409377, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 4 X 4 X 2=32 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MORC3 [Title/Abstract] AND PPP3R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MORC3 | GO:0006468 | protein phosphorylation | 17332504 |
| Hgene | MORC3 | GO:0007569 | cell aging | 17332504 |
| Hgene | MORC3 | GO:0018105 | peptidyl-serine phosphorylation | 17332504 |
| Hgene | MORC3 | GO:0048147 | negative regulation of fibroblast proliferation | 17332504 |
| Hgene | MORC3 | GO:0050821 | protein stabilization | 17332504 |
| Hgene | MORC3 | GO:0051457 | maintenance of protein location in nucleus | 17332504 |
| Tgene | PPP3R1 | GO:0033173 | calcineurin-NFAT signaling cascade | 22688515 |
| Tgene | PPP3R1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM549676 | MORC3 | chr21 | 37713757 | + | PPP3R1 | chr2 | 68451693 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000400485 | ENST00000234310 | MORC3 | chr21 | 37713757 | + | PPP3R1 | chr2 | 68451693 | - |
| 5CDS-intron | ENST00000400485 | ENST00000409752 | MORC3 | chr21 | 37713757 | + | PPP3R1 | chr2 | 68451693 | - |
| 5CDS-intron | ENST00000400485 | ENST00000409377 | MORC3 | chr21 | 37713757 | + | PPP3R1 | chr2 | 68451693 | - |
| 3UTR-intron | ENST00000487909 | ENST00000234310 | MORC3 | chr21 | 37713757 | + | PPP3R1 | chr2 | 68451693 | - |
| 3UTR-intron | ENST00000487909 | ENST00000409752 | MORC3 | chr21 | 37713757 | + | PPP3R1 | chr2 | 68451693 | - |
| 3UTR-intron | ENST00000487909 | ENST00000409377 | MORC3 | chr21 | 37713757 | + | PPP3R1 | chr2 | 68451693 | - |
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FusionProtFeatures for MORC3_PPP3R1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MORC3 | PPP3R1 |