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Fusion gene ID: 22258 |
FusionGeneSummary for MOB2_TNFAIP8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MOB2_TNFAIP8 | Fusion gene ID: 22258 | Hgene | Tgene | Gene symbol | MOB2 | TNFAIP8 | Gene ID | 81532 | 25816 |
| Gene name | MOB kinase activator 2 | TNF alpha induced protein 8 | |
| Synonyms | HCCA2 | GG2-1|MDC-3.13|NDED|SCC-S2|SCCS2 | |
| Cytomap | 11p15.5 | 5q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MOB kinase activator 2MOB2 Mps One Binder homologMps one binder kinase activator-like 2 | tumor necrosis factor alpha-induced protein 8NF-kappa-B-inducible DED-containing proteinTNF-induced protein GG2-1head and neck tumor and metastasis-related proteintumor necrosis factor, alpha induced protein 8 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q70IA6 | O95379 | |
| Ensembl transtripts involved in fusion gene | ENST00000329957, ENST00000526462, | ENST00000274456, ENST00000513374, ENST00000504771, ENST00000503646, ENST00000504642, ENST00000415806, | |
| Fusion gene scores | * DoF score | 9 X 12 X 2=216 | 5 X 4 X 4=80 |
| # samples | 12 | 6 | |
| ** MAII score | log2(12/216*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MOB2 [Title/Abstract] AND TNFAIP8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF868816 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000329957 | ENST00000274456 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000329957 | ENST00000513374 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000329957 | ENST00000504771 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000329957 | ENST00000503646 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000329957 | ENST00000504642 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000329957 | ENST00000415806 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000526462 | ENST00000274456 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000526462 | ENST00000513374 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000526462 | ENST00000504771 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000526462 | ENST00000503646 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000526462 | ENST00000504642 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
| intron-intron | ENST00000526462 | ENST00000415806 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
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FusionProtFeatures for MOB2_TNFAIP8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MOB2 | TNFAIP8 |