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Fusion gene ID: 22217 |
FusionGeneSummary for MMP14_PPM1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MMP14_PPM1A | Fusion gene ID: 22217 | Hgene | Tgene | Gene symbol | MMP14 | PPM1A | Gene ID | 4323 | 5494 |
| Gene name | matrix metallopeptidase 14 | protein phosphatase, Mg2+/Mn2+ dependent 1A | |
| Synonyms | MMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRS | PP2C-ALPHA|PP2CA|PP2Calpha | |
| Cytomap | 14q11.2 | 14q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | matrix metalloproteinase-14matrix metallopeptidase 14 (membrane-inserted)membrane type 1 metalloproteasemembrane-type-1 matrix metalloproteinase | protein phosphatase 1Aprotein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P50281 | P35813 | |
| Ensembl transtripts involved in fusion gene | ENST00000311852, ENST00000548162, | ENST00000325642, ENST00000529574, ENST00000395076, ENST00000325658, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 4 X 2=32 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MMP14 [Title/Abstract] AND PPM1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MMP14 | GO:0006508 | proteolysis | 15863497|24970228 |
| Hgene | MMP14 | GO:0030307 | positive regulation of cell growth | 22065321 |
| Hgene | MMP14 | GO:0030335 | positive regulation of cell migration | 22065321 |
| Tgene | PPM1A | GO:0010991 | negative regulation of SMAD protein complex assembly | 16751101 |
| Tgene | PPM1A | GO:0016055 | Wnt signaling pathway | 10644691 |
| Tgene | PPM1A | GO:0016311 | dephosphorylation | 10644691 |
| Tgene | PPM1A | GO:0030177 | positive regulation of Wnt signaling pathway | 10644691 |
| Tgene | PPM1A | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 16751101 |
| Tgene | PPM1A | GO:0035970 | peptidyl-threonine dephosphorylation | 11559703|20801214 |
| Tgene | PPM1A | GO:0045893 | positive regulation of transcription, DNA-templated | 10644691 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-XF-AAMW-01A | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000311852 | ENST00000325642 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 5CDS-5UTR | ENST00000311852 | ENST00000529574 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 5CDS-5UTR | ENST00000311852 | ENST00000395076 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 5CDS-5UTR | ENST00000311852 | ENST00000325658 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-3CDS | ENST00000548162 | ENST00000325642 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-5UTR | ENST00000548162 | ENST00000529574 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-5UTR | ENST00000548162 | ENST00000395076 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-5UTR | ENST00000548162 | ENST00000325658 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
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FusionProtFeatures for MMP14_PPM1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MMP14 | PPM1A |