	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 22192

FusionGeneSummary for MLST8_FOXRED2

Fusion gene summary

Fusion gene information	Fusion gene name: MLST8_FOXRED2
	Fusion gene ID: 22192
		Hgene	Tgene
	Gene symbol	MLST8	FOXRED2
	Gene ID	64223	80020
	Gene name	MTOR associated protein, LST8 homolog	FAD dependent oxidoreductase domain containing 2
	Synonyms	GBL\|GbetaL\|LST8\|POP3\|WAT1	ERFAD
	Cytomap	16p13.3	22q12.3
	Type of gene	protein-coding	protein-coding
	Description	target of rapamycin complex subunit LST8TORC subunit LST8gablemammalian lethal with SEC13 protein 8protein GbetaL	FAD-dependent oxidoreductase domain-containing protein 2ER flavoprotein associated with degradationendoplasmic reticulum flavoprotein associated with degradation
	Modification date	20180523	20180523
	UniProtAcc	Q9BVC4	Q8IWF2
	Ensembl transtripts involved in fusion gene	ENST00000564088, ENST00000382450, ENST00000569417, ENST00000561651, ENST00000301724, ENST00000397124, ENST00000565250, ENST00000301725,	ENST00000397224, ENST00000216187, ENST00000366463, ENST00000397223,
Fusion gene scores	* DoF score	1 X 1 X 1=1	2 X 2 X 2=8
	# samples	1	2
	** MAII score	log2(1/1*10)=3.32192809488736	log2(2/8*10)=1.32192809488736
Context	PubMed: MLST8 [Title/Abstract] AND FOXRED2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF813029	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000564088	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000564088	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000564088	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000564088	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000382450	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000382450	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000382450	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000382450	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000569417	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000569417	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000569417	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000569417	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
intron-intron	ENST00000561651	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
intron-intron	ENST00000561651	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
intron-intron	ENST00000561651	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
intron-intron	ENST00000561651	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000301724	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000301724	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000301724	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000301724	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000397124	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000397124	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000397124	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000397124	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000565250	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000565250	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000565250	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
5CDS-intron	ENST00000565250	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
3UTR-intron	ENST00000301725	ENST00000397224	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
3UTR-intron	ENST00000301725	ENST00000216187	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
3UTR-intron	ENST00000301725	ENST00000366463	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+
3UTR-intron	ENST00000301725	ENST00000397223	MLST8	chr16	2258580	+	FOXRED2	chr22	36887398	+

Top

FusionProtFeatures for MLST8_FOXRED2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MLST8 Q9BVC4	FOXRED2 Q8IWF2

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 22192

FusionGeneSummary for MLST8_FOXRED2

FusionProtFeatures for MLST8_FOXRED2