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Fusion gene ID: 22149

FusionGeneSummary for MLLT10_NAV1

Fusion gene summary

Fusion gene information	Fusion gene name: MLLT10_NAV1
	Fusion gene ID: 22149
		Hgene	Tgene
	Gene symbol	MLLT10	NAV1
	Gene ID	8028	89796
	Gene name	MLLT10, histone lysine methyltransferase DOT1L cofactor	neuron navigator 1
	Synonyms	AF10	POMFIL3\|STEERIN1\|UNC53H1
	Cytomap	10p12.31	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot	neuron navigator 1pore membrane and/or filament interacting like protein 3unc-53 homolog 1
	Modification date	20180522	20180523
	UniProtAcc	P55197	Q8NEY1
	Ensembl transtripts involved in fusion gene	ENST00000446906, ENST00000377072, ENST00000307729, ENST00000377059, ENST00000495130, ENST00000377100, ENST00000377091,	ENST00000367302, ENST00000367296, ENST00000295624, ENST00000367297, ENST00000367300, ENST00000367295, ENST00000469130,
Fusion gene scores	* DoF score	13 X 10 X 8=1040	7 X 6 X 3=126
	# samples	20	9
	** MAII score	log2(20/1040*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/126*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MLLT10 [Title/Abstract] AND NAV1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MLLT10	GO:0045944	positive regulation of transcription by RNA polymerase II	17868029

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-AN-A0AL-01A	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000446906	ENST00000367302	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000446906	ENST00000367296	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000446906	ENST00000295624	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000446906	ENST00000367297	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000446906	ENST00000367300	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000446906	ENST00000367295	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-intron	ENST00000446906	ENST00000469130	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377072	ENST00000367302	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377072	ENST00000367296	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377072	ENST00000295624	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377072	ENST00000367297	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377072	ENST00000367300	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377072	ENST00000367295	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-intron	ENST00000377072	ENST00000469130	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000307729	ENST00000367302	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000307729	ENST00000367296	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000307729	ENST00000295624	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000307729	ENST00000367297	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000307729	ENST00000367300	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000307729	ENST00000367295	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-intron	ENST00000307729	ENST00000469130	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377059	ENST00000367302	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377059	ENST00000367296	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377059	ENST00000295624	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377059	ENST00000367297	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377059	ENST00000367300	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-3UTR	ENST00000377059	ENST00000367295	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
5CDS-intron	ENST00000377059	ENST00000469130	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000495130	ENST00000367302	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000495130	ENST00000367296	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000495130	ENST00000295624	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000495130	ENST00000367297	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000495130	ENST00000367300	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000495130	ENST00000367295	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-intron	ENST00000495130	ENST00000469130	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377100	ENST00000367302	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377100	ENST00000367296	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377100	ENST00000295624	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377100	ENST00000367297	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377100	ENST00000367300	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377100	ENST00000367295	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-intron	ENST00000377100	ENST00000469130	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377091	ENST00000367302	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377091	ENST00000367296	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377091	ENST00000295624	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377091	ENST00000367297	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377091	ENST00000367300	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-3UTR	ENST00000377091	ENST00000367295	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+
intron-intron	ENST00000377091	ENST00000469130	MLLT10	chr10	21906136	+	NAV1	chr1	201790755	+

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FusionProtFeatures for MLLT10_NAV1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MLLT10 P55197	NAV1 Q8NEY1

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Fusion gene ID: 22149

FusionGeneSummary for MLLT10_NAV1

FusionProtFeatures for MLLT10_NAV1