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Fusion gene ID: 22097

FusionGeneSummary for MKLN1_DNM3

Fusion gene summary

Fusion gene information	Fusion gene name: MKLN1_DNM3
	Fusion gene ID: 22097
		Hgene	Tgene
	Gene symbol	MKLN1	DNM3
	Gene ID	4289	26052
	Gene name	muskelin 1	dynamin 3
	Synonyms	TWA2	Dyna III
	Cytomap	7q32.3	1q24.3
	Type of gene	protein-coding	protein-coding
	Description	muskelinmuskelin 1, intracellular mediator containing kelch motifs	dynamin-3T-dynamindynamin family memberdynamin, testicular
	Modification date	20180522	20180523
	UniProtAcc	Q9UL63	Q9UQ16
	Ensembl transtripts involved in fusion gene	ENST00000421797, ENST00000429546, ENST00000352689, ENST00000498778,	ENST00000358155, ENST00000367733, ENST00000355305, ENST00000367731, ENST00000520906,
Fusion gene scores	* DoF score	9 X 9 X 6=486	16 X 12 X 5=960
	# samples	9	15
	** MAII score	log2(9/486*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/960*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MKLN1 [Title/Abstract] AND DNM3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-DX-A1L2-01A	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000421797	ENST00000358155	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000421797	ENST00000367733	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000421797	ENST00000355305	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000421797	ENST00000367731	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000421797	ENST00000520906	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000429546	ENST00000358155	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000429546	ENST00000367733	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000429546	ENST00000355305	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000429546	ENST00000367731	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000429546	ENST00000520906	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
Frame-shift	ENST00000352689	ENST00000358155	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
Frame-shift	ENST00000352689	ENST00000367733	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
Frame-shift	ENST00000352689	ENST00000355305	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
Frame-shift	ENST00000352689	ENST00000367731	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
Frame-shift	ENST00000352689	ENST00000520906	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000498778	ENST00000358155	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000498778	ENST00000367733	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000498778	ENST00000355305	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000498778	ENST00000367731	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+
intron-3CDS	ENST00000498778	ENST00000520906	MKLN1	chr7	131012756	+	DNM3	chr1	171956796	+

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FusionProtFeatures for MKLN1_DNM3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MKLN1 Q9UL63	DNM3 Q9UQ16

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Fusion gene ID: 22097

FusionGeneSummary for MKLN1_DNM3

FusionProtFeatures for MKLN1_DNM3