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Fusion gene ID: 22031 |
FusionGeneSummary for MIR548H3_NUP93 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MIR548H3_NUP93 | Fusion gene ID: 22031 | Hgene | Tgene | Gene symbol | MIR548H3 | NUP93 | Gene ID | 100302287 | 9688 |
| Gene name | microRNA 548h-3 | nucleoporin 93 | |
| Synonyms | MIR548H-3|MIRN548H3|hsa-mir-548h-3 | NIC96 | |
| Cytomap | 17p12 | 16q13 | |
| Type of gene | ncRNA | protein-coding | |
| Description | - | nuclear pore complex protein Nup9393 kDa nucleoporinnucleoporin 93kDanucleoporin Nup93 | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | Q8N1F7 | ||
| Ensembl transtripts involved in fusion gene | ENST00000408771, | ENST00000308159, ENST00000569842, ENST00000564887, ENST00000569595, ENST00000542526, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 8 X 8 X 5=320 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/320*10)=-2.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MIR548H3 [Title/Abstract] AND NUP93 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NUP93 | GO:0006998 | nuclear envelope organization | 26878725 |
| Tgene | NUP93 | GO:0051292 | nuclear pore complex assembly | 26878725 |
| Tgene | NUP93 | GO:0060391 | positive regulation of SMAD protein signal transduction | 26878725 |
| Tgene | NUP93 | GO:0060395 | SMAD protein signal transduction | 26878725 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AU124982 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000408771 | ENST00000308159 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
| intron-3CDS | ENST00000408771 | ENST00000569842 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
| intron-3CDS | ENST00000408771 | ENST00000564887 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
| intron-3UTR | ENST00000408771 | ENST00000569595 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
| intron-3UTR | ENST00000408771 | ENST00000542526 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
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FusionProtFeatures for MIR548H3_NUP93 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MIR548H3 | NUP93 |