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Fusion gene ID: 21993 |
FusionGeneSummary for MIPOL1_NPAS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MIPOL1_NPAS3 | Fusion gene ID: 21993 | Hgene | Tgene | Gene symbol | MIPOL1 | NPAS3 | Gene ID | 145282 | 64067 |
| Gene name | mirror-image polydactyly 1 | neuronal PAS domain protein 3 | |
| Synonyms | CCDC193 | MOP6|PASD6|bHLHe12 | |
| Cytomap | 14q13.3-q21.1 | 14q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mirror-image polydactyly gene 1 protein | neuronal PAS domain-containing protein 3PAS domain-containing protein 6basic-helix-loop-helix-PAS protein MOP6class E basic helix-loop-helix protein 12member of PAS protein 6neuronal PAS3 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8TD10 | Q8IXF0 | |
| Ensembl transtripts involved in fusion gene | ENST00000536774, ENST00000327441, ENST00000539062, ENST00000556451, ENST00000396294, ENST00000545536, ENST00000537471, ENST00000539174, | ENST00000551492, ENST00000346562, ENST00000341321, ENST00000548645, ENST00000356141, ENST00000357798, ENST00000547068, ENST00000551008, ENST00000550662, | |
| Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 9 X 7 X 6=378 |
| # samples | 11 | 10 | |
| ** MAII score | log2(11/490*10)=-2.15527822547791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MIPOL1 [Title/Abstract] AND NPAS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-8358-01A | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000536774 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000536774 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000536774 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000536774 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000536774 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000536774 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000536774 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000536774 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000536774 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000327441 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000327441 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000539062 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000539062 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556451 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000556451 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396294 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000396294 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000545536 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000545536 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000537471 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000537471 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000551492 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000346562 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000341321 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000548645 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000356141 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000357798 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000547068 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-intron | ENST00000539174 | ENST00000551008 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
| intron-3UTR | ENST00000539174 | ENST00000550662 | MIPOL1 | chr14 | 37777724 | + | NPAS3 | chr14 | 34081611 | + |
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FusionProtFeatures for MIPOL1_NPAS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MIPOL1 | NPAS3 |