|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 21820 |
FusionGeneSummary for MGA_STRC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MGA_STRC | Fusion gene ID: 21820 | Hgene | Tgene | Gene symbol | MGA | STRC | Gene ID | 23269 | 161497 |
| Gene name | MGA, MAX dimerization protein | stereocilin | |
| Synonyms | MAD5|MXD5 | DFNB16 | |
| Cytomap | 15q15.1 | 15q15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAX gene-associated proteinMAX dimerization protein 5 | stereocilin | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IWI9 | Q7RTU9 | |
| Ensembl transtripts involved in fusion gene | ENST00000568630, ENST00000545763, ENST00000389936, ENST00000219905, ENST00000566586, ENST00000570161, | ENST00000450892, ENST00000541030, | |
| Fusion gene scores | * DoF score | 14 X 10 X 9=1260 | 2 X 1 X 2=4 |
| # samples | 14 | 2 | |
| ** MAII score | log2(14/1260*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MGA [Title/Abstract] AND STRC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-MB-A8JL-01A | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000568630 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| 3UTR-3CDS | ENST00000568630 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000545763 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000545763 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000389936 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000389936 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000219905 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000219905 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000566586 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000566586 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000570161 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
| intron-3CDS | ENST00000570161 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
Top |
FusionProtFeatures for MGA_STRC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MGA | STRC |