|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 2179 |
FusionGeneSummary for APLP2_HDHD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APLP2_HDHD2 | Fusion gene ID: 2179 | Hgene | Tgene | Gene symbol | APLP2 | HDHD2 | Gene ID | 334 | 84064 |
| Gene name | amyloid beta precursor like protein 2 | haloacid dehalogenase like hydrolase domain containing 2 | |
| Synonyms | APLP-2|APPH|APPL2|CDEBP | 3110052N05Rik|HEL-S-301 | |
| Cytomap | 11q24.3 | 18q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | amyloid-like protein 2CDEI box-binding proteinamyloid beta (A4) precursor-like protein 2amyloid precursor protein homolog HSD-2testicular tissue protein Li 23 | haloacid dehalogenase-like hydrolase domain-containing protein 2epididymis secretory protein Li 301 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q06481 | Q9H0R4 | |
| Ensembl transtripts involved in fusion gene | ENST00000532456, ENST00000539648, ENST00000528499, ENST00000263574, ENST00000345598, ENST00000338167, ENST00000278756, ENST00000543137, | ENST00000300605, ENST00000587841, | |
| Fusion gene scores | * DoF score | 24 X 17 X 11=4488 | 2 X 2 X 1=4 |
| # samples | 29 | 2 | |
| ** MAII score | log2(29/4488*10)=-3.95194787059386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: APLP2 [Title/Abstract] AND HDHD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP316568 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000532456 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| intron-intron | ENST00000532456 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-3UTR | ENST00000539648 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-intron | ENST00000539648 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-3UTR | ENST00000528499 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-intron | ENST00000528499 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-3UTR | ENST00000263574 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-intron | ENST00000263574 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| intron-3UTR | ENST00000345598 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| intron-intron | ENST00000345598 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-3UTR | ENST00000338167 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-intron | ENST00000338167 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-3UTR | ENST00000278756 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-intron | ENST00000278756 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-3UTR | ENST00000543137 | ENST00000300605 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
| 5CDS-intron | ENST00000543137 | ENST00000587841 | APLP2 | chr11 | 129992298 | + | HDHD2 | chr18 | 44634700 | - |
Top |
FusionProtFeatures for APLP2_HDHD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APLP2 | HDHD2 |