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Fusion gene ID: 21775 |
FusionGeneSummary for MFSD2A_MFSD2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MFSD2A_MFSD2A | Fusion gene ID: 21775 | Hgene | Tgene | Gene symbol | MFSD2A | MFSD2A | Gene ID | 84879 | 84879 |
| Gene name | major facilitator superfamily domain containing 2A | major facilitator superfamily domain containing 2A | |
| Synonyms | MCPH15|MFSD2|NLS1 | MCPH15|MFSD2|NLS1 | |
| Cytomap | 1p34.2 | 1p34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1 | sodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1 | |
| Modification date | 20180329 | 20180329 | |
| UniProtAcc | Q8NA29 | Q8NA29 | |
| Ensembl transtripts involved in fusion gene | ENST00000372811, ENST00000420632, ENST00000372809, ENST00000480630, | ENST00000372811, ENST00000420632, ENST00000372809, ENST00000480630, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 6 X 6 X 3=108 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MFSD2A [Title/Abstract] AND MFSD2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MFSD2A | GO:0051977 | lysophospholipid transport | 24828044 |
| Tgene | MFSD2A | GO:0051977 | lysophospholipid transport | 24828044 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF995041 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - | ||
| ChiTaRS3.1 | BF995186 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000372811 | ENST00000372811 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000372811 | ENST00000420632 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000372811 | ENST00000372809 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| 5CDS-3UTR | ENST00000372811 | ENST00000480630 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000420632 | ENST00000372811 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000420632 | ENST00000420632 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000420632 | ENST00000372809 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| 5CDS-3UTR | ENST00000420632 | ENST00000480630 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000372809 | ENST00000372811 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000372809 | ENST00000420632 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| In-frame | ENST00000372809 | ENST00000372809 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| 5CDS-3UTR | ENST00000372809 | ENST00000480630 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| 3UTR-3CDS | ENST00000480630 | ENST00000372811 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| 3UTR-3CDS | ENST00000480630 | ENST00000420632 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| 3UTR-3CDS | ENST00000480630 | ENST00000372809 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
| 3UTR-3UTR | ENST00000480630 | ENST00000480630 | MFSD2A | chr1 | 40433513 | + | MFSD2A | chr1 | 40434061 | - |
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FusionProtFeatures for MFSD2A_MFSD2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MFSD2A | MFSD2A |