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Fusion gene ID: 21765 |
FusionGeneSummary for MFSD11_NR2C2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MFSD11_NR2C2 | Fusion gene ID: 21765 | Hgene | Tgene | Gene symbol | MFSD11 | NR2C2 | Gene ID | 79157 | 7182 |
| Gene name | major facilitator superfamily domain containing 11 | nuclear receptor subfamily 2 group C member 2 | |
| Synonyms | ET | TAK1|TR4 | |
| Cytomap | 17q25.1-q25.2 | 3p25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UNC93-like protein MFSD11major facilitator superfamily domain-containing protein 11protein ET | nuclear receptor subfamily 2 group C member 2Nuclear hormone receptor TR4orphan nuclear receptor TAK1orphan nuclear receptor TR4orphan receptor TR4testicular nuclear receptor 4 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O43934 | P49116 | |
| Ensembl transtripts involved in fusion gene | ENST00000586622, ENST00000588460, ENST00000591864, ENST00000590393, ENST00000593181, ENST00000355954, ENST00000336509, ENST00000590514, ENST00000590070, | ENST00000425241, ENST00000323373, ENST00000393102, ENST00000406272, ENST00000478572, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 6 X 2=72 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MFSD11 [Title/Abstract] AND NR2C2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NR2C2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9556573|10644740 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | U10990 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000586622 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000586622 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000586622 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000586622 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000586622 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000588460 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000588460 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000588460 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000588460 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000588460 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000591864 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000591864 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000591864 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-intron | ENST00000591864 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-intron | ENST00000591864 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000590393 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000590393 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000590393 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-intron | ENST00000590393 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-intron | ENST00000590393 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000593181 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000593181 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000593181 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000593181 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000593181 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000355954 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000355954 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000355954 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000355954 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000355954 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000336509 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000336509 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000336509 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000336509 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000336509 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000590514 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000590514 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-5UTR | ENST00000590514 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000590514 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| 5CDS-intron | ENST00000590514 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000590070 | ENST00000425241 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000590070 | ENST00000323373 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-5UTR | ENST00000590070 | ENST00000393102 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-intron | ENST00000590070 | ENST00000406272 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
| intron-intron | ENST00000590070 | ENST00000478572 | MFSD11 | chr17 | 74738105 | + | NR2C2 | chr3 | 15045391 | + |
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FusionProtFeatures for MFSD11_NR2C2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MFSD11 | NR2C2 |