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Fusion gene ID: 21741 |
FusionGeneSummary for MFAP1_STRC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MFAP1_STRC | Fusion gene ID: 21741 | Hgene | Tgene | Gene symbol | MFAP1 | STRC | Gene ID | 4236 | 161497 |
| Gene name | microfibril associated protein 1 | stereocilin | |
| Synonyms | AMP | DFNB16 | |
| Cytomap | 15q15.3 | 15q15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microfibrillar-associated protein 1microfibrillar associated protein 1 | stereocilin | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P55081 | Q7RTU9 | |
| Ensembl transtripts involved in fusion gene | ENST00000267812, | ENST00000450892, ENST00000541030, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 2 X 1 X 2=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MFAP1 [Title/Abstract] AND STRC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-5516-01A | MFAP1 | chr15 | 44105185 | - | STRC | chr15 | 43897597 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000267812 | ENST00000450892 | MFAP1 | chr15 | 44105185 | - | STRC | chr15 | 43897597 | - |
| In-frame | ENST00000267812 | ENST00000541030 | MFAP1 | chr15 | 44105185 | - | STRC | chr15 | 43897597 | - |
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FusionProtFeatures for MFAP1_STRC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MFAP1 | STRC |