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Fusion gene ID: 21733 |
FusionGeneSummary for MET_WNT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MET_WNT2 | Fusion gene ID: 21733 | Hgene | Tgene | Gene symbol | MET | WNT2 | Gene ID | 8731 | 7472 |
| Gene name | RNA guanine-7 methyltransferase | Wnt family member 2 | |
| Synonyms | CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet | INT1L1|IRP | |
| Cytomap | 18p11.21 | 7q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase | protein Wnt-2Int-1-related proteinint-1-like protein 1secreted growth factorwingless-type MMTV integration site family member 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P08581 | P09544 | |
| Ensembl transtripts involved in fusion gene | ENST00000397752, ENST00000318493, ENST00000436117, ENST00000495962, ENST00000539704, | ENST00000265441, | |
| Fusion gene scores | * DoF score | 8 X 7 X 8=448 | 4 X 2 X 3=24 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/448*10)=-2.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MET [Title/Abstract] AND WNT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MET | GO:0006370 | 7-methylguanosine mRNA capping | 27422871 |
| Tgene | WNT2 | GO:0007267 | cell-cell signaling | 10557084 |
| Tgene | WNT2 | GO:0008284 | positive regulation of cell proliferation | 10347172 |
| Tgene | WNT2 | GO:0016055 | Wnt signaling pathway | 10557084 |
| Tgene | WNT2 | GO:0033278 | cell proliferation in midbrain | 20018874 |
| Tgene | WNT2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20018874 |
| Tgene | WNT2 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 10557084 |
| Tgene | WNT2 | GO:0060070 | canonical Wnt signaling pathway | 10347172|20018874 |
| Tgene | WNT2 | GO:1904948 | midbrain dopaminergic neuron differentiation | 20018874 |
| Tgene | WNT2 | GO:1904954 | canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | 20018874 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-44-7662-01A | MET | chr7 | 116417523 | + | WNT2 | chr7 | 116937930 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000397752 | ENST00000265441 | MET | chr7 | 116417523 | + | WNT2 | chr7 | 116937930 | - |
| Frame-shift | ENST00000318493 | ENST00000265441 | MET | chr7 | 116417523 | + | WNT2 | chr7 | 116937930 | - |
| intron-3CDS | ENST00000436117 | ENST00000265441 | MET | chr7 | 116417523 | + | WNT2 | chr7 | 116937930 | - |
| intron-3CDS | ENST00000495962 | ENST00000265441 | MET | chr7 | 116417523 | + | WNT2 | chr7 | 116937930 | - |
| 5UTR-3CDS | ENST00000539704 | ENST00000265441 | MET | chr7 | 116417523 | + | WNT2 | chr7 | 116937930 | - |
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FusionProtFeatures for MET_WNT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MET | WNT2 |