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Fusion gene ID: 21673 |
FusionGeneSummary for METTL15_SLC1A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METTL15_SLC1A3 | Fusion gene ID: 21673 | Hgene | Tgene | Gene symbol | METTL15 | SLC1A3 | Gene ID | 196074 | 6507 |
| Gene name | methyltransferase like 15 | solute carrier family 1 member 3 | |
| Synonyms | METT5D1 | EA6|EAAT1|GLAST|GLAST1 | |
| Cytomap | 11p14.1 | 5p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable methyltransferase-like protein 15methyltransferase 5 domain containing 1methyltransferase 5 domain-containing protein 1probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1putative S-adenosyl-L-methionine-dependent methyltransf | excitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | A6NJ78 | P43003 | |
| Ensembl transtripts involved in fusion gene | ENST00000406787, ENST00000342303, ENST00000407364, ENST00000303459, ENST00000403099, ENST00000379199, | ENST00000265113, ENST00000506725, ENST00000381918, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 9 X 6=540 |
| # samples | 1 | 12 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: METTL15 [Title/Abstract] AND SLC1A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC1A3 | GO:0015813 | L-glutamate transmembrane transport | 26690923 |
| Tgene | SLC1A3 | GO:0051938 | L-glutamate import | 7521911 |
| Tgene | SLC1A3 | GO:0070779 | D-aspartate import across plasma membrane | 7521911 |
| Tgene | SLC1A3 | GO:0071805 | potassium ion transmembrane transport | 20477940 |
| Tgene | SLC1A3 | GO:0098712 | L-glutamate import across plasma membrane | 26690923 |
| Tgene | SLC1A3 | GO:0140009 | L-aspartate import across plasma membrane | 20477940 |
| Tgene | SLC1A3 | GO:1902476 | chloride transmembrane transport | 20477940 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1Y0-01A | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000406787 | ENST00000265113 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000406787 | ENST00000506725 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000406787 | ENST00000381918 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| In-frame | ENST00000342303 | ENST00000265113 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000342303 | ENST00000506725 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000342303 | ENST00000381918 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| In-frame | ENST00000407364 | ENST00000265113 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000407364 | ENST00000506725 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000407364 | ENST00000381918 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| In-frame | ENST00000303459 | ENST00000265113 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000303459 | ENST00000506725 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| 5CDS-intron | ENST00000303459 | ENST00000381918 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| intron-3CDS | ENST00000403099 | ENST00000265113 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| intron-intron | ENST00000403099 | ENST00000506725 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| intron-intron | ENST00000403099 | ENST00000381918 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| intron-3CDS | ENST00000379199 | ENST00000265113 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| intron-intron | ENST00000379199 | ENST00000506725 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
| intron-intron | ENST00000379199 | ENST00000381918 | METTL15 | chr11 | 28232745 | + | SLC1A3 | chr5 | 36674151 | + |
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FusionProtFeatures for METTL15_SLC1A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METTL15 | SLC1A3 |