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Fusion gene ID: 21661 |
FusionGeneSummary for METAP1_EIF4E |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METAP1_EIF4E | Fusion gene ID: 21661 | Hgene | Tgene | Gene symbol | METAP1 | EIF4E | Gene ID | 23173 | 1977 |
| Gene name | methionyl aminopeptidase 1 | eukaryotic translation initiation factor 4E | |
| Synonyms | MAP1A|MetAP1A | AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E | |
| Cytomap | 4q23 | 4q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methionine aminopeptidase 1MAP 1metAP 1peptidase M 1 | eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P53582 | P06730 | |
| Ensembl transtripts involved in fusion gene | ENST00000296411, ENST00000506548, ENST00000544031, | ENST00000450253, ENST00000280892, ENST00000504432, ENST00000505992, ENST00000504472, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: METAP1 [Title/Abstract] AND EIF4E [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EIF4E | GO:0006417 | regulation of translation | 22578813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A1IL-01A | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000296411 | ENST00000450253 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| In-frame | ENST00000296411 | ENST00000280892 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| In-frame | ENST00000296411 | ENST00000504432 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| In-frame | ENST00000296411 | ENST00000505992 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| 5CDS-5UTR | ENST00000296411 | ENST00000504472 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000450253 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000280892 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000504432 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000505992 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-5UTR | ENST00000506548 | ENST00000504472 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000450253 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000280892 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000504432 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000505992 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-5UTR | ENST00000544031 | ENST00000504472 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
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FusionProtFeatures for METAP1_EIF4E |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METAP1 | EIF4E |