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Fusion gene ID: 21659 |
FusionGeneSummary for METAP1D_HAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METAP1D_HAT1 | Fusion gene ID: 21659 | Hgene | Tgene | Gene symbol | METAP1D | HAT1 | Gene ID | 254042 | 8520 |
| Gene name | methionyl aminopeptidase type 1D, mitochondrial | histone acetyltransferase 1 | |
| Synonyms | MAP 1D|MAP1D|MetAP 1D|Metap1l | KAT1 | |
| Cytomap | 2q31.1 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methionine aminopeptidase 1D, mitochondrialCDS of metAP-3 within PCR fragmentmetAP 1Dpeptidase M 1D | histone acetyltransferase type B catalytic subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6UB28 | O14929 | |
| Ensembl transtripts involved in fusion gene | ENST00000315796, ENST00000488581, | ENST00000392584, ENST00000460481, ENST00000264108, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: METAP1D [Title/Abstract] AND HAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HAT1 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Tgene | HAT1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Tgene | HAT1 | GO:0043967 | histone H4 acetylation | 22615379 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1549-01A | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315796 | ENST00000392584 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| 5CDS-intron | ENST00000315796 | ENST00000460481 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| 5CDS-intron | ENST00000315796 | ENST00000264108 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| intron-3CDS | ENST00000488581 | ENST00000392584 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| intron-intron | ENST00000488581 | ENST00000460481 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| intron-intron | ENST00000488581 | ENST00000264108 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
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FusionProtFeatures for METAP1D_HAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METAP1D | HAT1 |