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Fusion gene ID: 21620 |
FusionGeneSummary for MEGF8_MEGF8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEGF8_MEGF8 | Fusion gene ID: 21620 | Hgene | Tgene | Gene symbol | MEGF8 | MEGF8 | Gene ID | 1954 | 1954 |
| Gene name | multiple EGF like domains 8 | multiple EGF like domains 8 | |
| Synonyms | C19orf49|CRPT2|EGFL4|SBP1 | C19orf49|CRPT2|EGFL4|SBP1 | |
| Cytomap | 19q13.2 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | multiple epidermal growth factor-like domains protein 8EGF-like domain-containing protein 4EGF-like-domain, multiple 4HBV pre-S2-binding protein 1HBV pre-s2 binding protein 1epidermal growth factor-like protein 4hepatitis B virus pre-S2-binding prot | multiple epidermal growth factor-like domains protein 8EGF-like domain-containing protein 4EGF-like-domain, multiple 4HBV pre-S2-binding protein 1HBV pre-s2 binding protein 1epidermal growth factor-like protein 4hepatitis B virus pre-S2-binding prot | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q7Z7M0 | Q7Z7M0 | |
| Ensembl transtripts involved in fusion gene | ENST00000334370, ENST00000251268, ENST00000378073, | ENST00000334370, ENST00000251268, ENST00000378073, | |
| Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 3 X 3 X 2=18 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MEGF8 [Title/Abstract] AND MEGF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU607742 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000334370 | ENST00000334370 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000334370 | ENST00000251268 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000334370 | ENST00000378073 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000251268 | ENST00000334370 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000251268 | ENST00000251268 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000251268 | ENST00000378073 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000378073 | ENST00000334370 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000378073 | ENST00000251268 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
| intron-intron | ENST00000378073 | ENST00000378073 | MEGF8 | chr6 | 33665400 | + | MEGF8 | chr6 | 33668274 | - |
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FusionProtFeatures for MEGF8_MEGF8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEGF8 | MEGF8 |