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Fusion gene ID: 21591 |
FusionGeneSummary for MEF2A_SV2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEF2A_SV2B | Fusion gene ID: 21591 | Hgene | Tgene | Gene symbol | MEF2A | SV2B | Gene ID | 4205 | 9899 |
| Gene name | myocyte enhancer factor 2A | synaptic vesicle glycoprotein 2B | |
| Synonyms | ADCAD1|RSRFC4|RSRFC9|mef2 | HsT19680 | |
| Cytomap | 15q26.3 | 15q26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myocyte-specific enhancer factor 2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)serum response factor-like protein 1 | synaptic vesicle glycoprotein 2Bsynaptic vesicle protein 2B homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q02078 | Q7L1I2 | |
| Ensembl transtripts involved in fusion gene | ENST00000453228, ENST00000354410, ENST00000558856, ENST00000558812, ENST00000338042, ENST00000557785, ENST00000449277, ENST00000557942, | ENST00000545111, ENST00000394232, ENST00000557291, ENST00000330276, | |
| Fusion gene scores | * DoF score | 5 X 6 X 4=120 | 4 X 4 X 3=48 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MEF2A [Title/Abstract] AND SV2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MEF2A | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16484498 |
| Hgene | MEF2A | GO:0000165 | MAPK cascade | 9858528 |
| Hgene | MEF2A | GO:0006351 | transcription, DNA-templated | 16043483 |
| Hgene | MEF2A | GO:0010613 | positive regulation of cardiac muscle hypertrophy | 24161931 |
| Hgene | MEF2A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7760790|9858528|10748098|15466416|20590529|21468593 |
| Hgene | MEF2A | GO:0071277 | cellular response to calcium ion | 16484498 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1KY-01A | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000453228 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000453228 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000453228 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000453228 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000354410 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000354410 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000354410 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000354410 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| intron-5UTR | ENST00000558856 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| intron-5UTR | ENST00000558856 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| intron-3UTR | ENST00000558856 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| intron-3UTR | ENST00000558856 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000558812 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000558812 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000558812 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000558812 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000338042 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000338042 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000338042 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000338042 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000557785 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000557785 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000557785 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000557785 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000449277 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000449277 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000449277 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000449277 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000557942 | ENST00000545111 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-5UTR | ENST00000557942 | ENST00000394232 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000557942 | ENST00000557291 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
| 5CDS-3UTR | ENST00000557942 | ENST00000330276 | MEF2A | chr15 | 100230633 | + | SV2B | chr15 | 91795049 | + |
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FusionProtFeatures for MEF2A_SV2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEF2A | SV2B |