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Fusion gene ID: 21570 |
FusionGeneSummary for MED26_ZNF99 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED26_ZNF99 | Fusion gene ID: 21570 | Hgene | Tgene | Gene symbol | MED26 | ZNF99 | Gene ID | 9441 | 7652 |
| Gene name | mediator complex subunit 26 | zinc finger protein 99 | |
| Synonyms | CRSP7|CRSP70 | C19orf9|F8281 | |
| Cytomap | 19p13.11 | 19p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 26ARC70CRSP complex subunit 7activator-recruited cofactor 70 kDa componentcofactor required for Sp1 transcriptional activation subunit 7cofactor required for Sp1 transcriptional activation, subunit | zinc finger protein 99zinc finger protein ENSP00000375192 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O95402 | A8MXY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000263390, | ENST00000397104, ENST00000596209, | |
| Fusion gene scores | * DoF score | 15 X 6 X 10=900 | 2 X 1 X 1=2 |
| # samples | 15 | 1 | |
| ** MAII score | log2(15/900*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/2*10)=2.32192809488736 | |
| Context | PubMed: MED26 [Title/Abstract] AND ZNF99 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED26 | GO:0006357 | regulation of transcription by RNA polymerase II | 15989967 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-B5-A5OE-01A | MED26 | chr19 | 16738683 | - | ZNF99 | chr19 | 22952126 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263390 | ENST00000397104 | MED26 | chr19 | 16738683 | - | ZNF99 | chr19 | 22952126 | - |
| In-frame | ENST00000263390 | ENST00000596209 | MED26 | chr19 | 16738683 | - | ZNF99 | chr19 | 22952126 | - |
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FusionProtFeatures for MED26_ZNF99 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED26 | ZNF99 |