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Fusion gene ID: 21540 |
FusionGeneSummary for MED24_IKZF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED24_IKZF3 | Fusion gene ID: 21540 | Hgene | Tgene | Gene symbol | MED24 | IKZF3 | Gene ID | 9862 | 22806 |
| Gene name | mediator complex subunit 24 | IKAROS family zinc finger 3 | |
| Synonyms | ARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100 | AIO|AIOLOS|ZNFN1A3 | |
| Cytomap | 17q21.1 | 17q12-q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10 | zinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75448 | Q9UKT9 | |
| Ensembl transtripts involved in fusion gene | ENST00000394126, ENST00000356271, ENST00000394128, ENST00000394127, ENST00000501516, ENST00000479829, | ENST00000346872, ENST00000394189, ENST00000439167, ENST00000535189, ENST00000377944, ENST00000377945, ENST00000377952, ENST00000377958, ENST00000346243, ENST00000350532, ENST00000351680, ENST00000467757, ENST00000439016, ENST00000583368, | |
| Fusion gene scores | * DoF score | 14 X 9 X 8=1008 | 27 X 9 X 12=2916 |
| # samples | 15 | 34 | |
| ** MAII score | log2(15/1008*10)=-2.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(34/2916*10)=-3.10038406818924 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED24 [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED24 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 12218053 |
| Hgene | MED24 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 11867769 |
| Hgene | MED24 | GO:0030521 | androgen receptor signaling pathway | 12218053 |
| Hgene | MED24 | GO:0045893 | positive regulation of transcription, DNA-templated | 10198638 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A14P-01A | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394126 | ENST00000346872 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000394189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000439167 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000535189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000377944 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000377945 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000377952 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000377958 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000346243 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000350532 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000351680 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000467757 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000439016 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394126 | ENST00000583368 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| Frame-shift | ENST00000356271 | ENST00000346872 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000394189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000439167 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000535189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000377944 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000377945 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000377952 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000377958 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000346243 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000350532 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000351680 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000467757 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000439016 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000356271 | ENST00000583368 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| Frame-shift | ENST00000394128 | ENST00000346872 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000394189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000439167 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000535189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000377944 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000377945 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000377952 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000377958 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000346243 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000350532 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000351680 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000467757 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000439016 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394128 | ENST00000583368 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| Frame-shift | ENST00000394127 | ENST00000346872 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000394189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000439167 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000535189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000377944 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000377945 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000377952 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000377958 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000346243 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000350532 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000351680 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000467757 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000439016 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000394127 | ENST00000583368 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| In-frame | ENST00000501516 | ENST00000346872 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000394189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000439167 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000535189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000377944 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000377945 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000377952 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000377958 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000346243 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000350532 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000351680 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000467757 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000439016 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| 5CDS-intron | ENST00000501516 | ENST00000583368 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-3CDS | ENST00000479829 | ENST00000346872 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000394189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000439167 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000535189 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000377944 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000377945 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000377952 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000377958 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000346243 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000350532 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000351680 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000467757 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000439016 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
| intron-intron | ENST00000479829 | ENST00000583368 | MED24 | chr17 | 38176526 | - | IKZF3 | chr17 | 37949186 | - |
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FusionProtFeatures for MED24_IKZF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED24 | IKZF3 |