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Fusion gene ID: 21451 |
FusionGeneSummary for MED13L_GTPBP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED13L_GTPBP4 | Fusion gene ID: 21451 | Hgene | Tgene | Gene symbol | MED13L | GTPBP4 | Gene ID | 23389 | 23560 |
| Gene name | mediator complex subunit 13 like | GTP binding protein 4 | |
| Synonyms | MRFACD|PROSIT240|THRAP2|TRAP240L | CRFG|NGB|NOG1 | |
| Cytomap | 12q24.21 | 10p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 13-likethyroid hormone receptor-associated protein 2thyroid hormone receptor-associated protein complex 240 kDa component-like | nucleolar GTP-binding protein 1G protein-binding protein CRFGGTP-binding protein NGBchronic renal failure gene protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q71F56 | Q9BZE4 | |
| Ensembl transtripts involved in fusion gene | ENST00000281928, ENST00000551197, | ENST00000360803, ENST00000491635, ENST00000538293, ENST00000545048, | |
| Fusion gene scores | * DoF score | 21 X 13 X 12=3276 | 3 X 3 X 1=9 |
| # samples | 23 | 3 | |
| ** MAII score | log2(23/3276*10)=-3.83222959069663 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MED13L [Title/Abstract] AND GTPBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GTPBP4 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 17210637 |
| Tgene | GTPBP4 | GO:0022408 | negative regulation of cell-cell adhesion | 17210637 |
| Tgene | GTPBP4 | GO:0030336 | negative regulation of cell migration | 17210637 |
| Tgene | GTPBP4 | GO:0031397 | negative regulation of protein ubiquitination | 17210637 |
| Tgene | GTPBP4 | GO:0050821 | protein stabilization | 17210637 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG988299 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000281928 | ENST00000360803 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| 5CDS-intron | ENST00000281928 | ENST00000491635 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| 5CDS-intron | ENST00000281928 | ENST00000538293 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| 5CDS-intron | ENST00000281928 | ENST00000545048 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| intron-intron | ENST00000551197 | ENST00000360803 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| intron-intron | ENST00000551197 | ENST00000491635 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| intron-intron | ENST00000551197 | ENST00000538293 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
| intron-intron | ENST00000551197 | ENST00000545048 | MED13L | chr12 | 116403886 | - | GTPBP4 | chr10 | 1058602 | - |
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FusionProtFeatures for MED13L_GTPBP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED13L | GTPBP4 |