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Fusion gene ID: 21419

FusionGeneSummary for MECOM_ARMC8

Fusion gene summary

Fusion gene information	Fusion gene name: MECOM_ARMC8
	Fusion gene ID: 21419
		Hgene	Tgene
	Gene symbol	MECOM	ARMC8
	Gene ID	2122	25852
	Gene name	MDS1 and EVI1 complex locus	armadillo repeat containing 8
	Synonyms	AML1-EVI-1\|EVI1\|KMT8E\|MDS1\|MDS1-EVI1\|PRDM3\|RUSAT2	GID5\|HSPC056\|S863-2\|VID28
	Cytomap	3q26.2	3q22.3
	Type of gene	protein-coding	protein-coding
	Description	MDS1 and EVI1 complex locus proteinMDS1 and EVI1 complex locus protein EVI1AML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein 1onc	armadillo repeat-containing protein 8GID complex subunit 5, VID28 homolog
	Modification date	20180522	20180523
	UniProtAcc	Q03112	Q8IUR7
	Ensembl transtripts involved in fusion gene	ENST00000264674, ENST00000392736, ENST00000464456, ENST00000472280, ENST00000494292, ENST00000468789, ENST00000460814, ENST00000433243, ENST00000485957,	ENST00000481646, ENST00000469044, ENST00000491704, ENST00000358441, ENST00000489213, ENST00000461822, ENST00000485396, ENST00000471453, ENST00000470821, ENST00000393058, ENST00000538260,
Fusion gene scores	* DoF score	15 X 7 X 10=1050	5 X 5 X 4=100
	# samples	21	5
	** MAII score	log2(21/1050*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MECOM [Title/Abstract] AND ARMC8 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MECOM	GO:0045892	negative regulation of transcription, DNA-templated	10856240\|11568182
Hgene	MECOM	GO:0045893	positive regulation of transcription, DNA-templated	11568182\|19767769
Hgene	MECOM	GO:0051726	regulation of cell cycle	11568182

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-43-A474-01A	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000264674	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000264674	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000264674	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000264674	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000392736	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000392736	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000392736	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000392736	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000464456	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000464456	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000464456	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000464456	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000472280	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000472280	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000472280	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000472280	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
In-frame	ENST00000494292	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
In-frame	ENST00000494292	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
In-frame	ENST00000494292	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5CDS-intron	ENST00000494292	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000468789	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000468789	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000468789	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000468789	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000460814	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000460814	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000460814	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000460814	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000433243	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000433243	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-3CDS	ENST00000433243	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
intron-intron	ENST00000433243	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-3CDS	ENST00000485957	ENST00000481646	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-3CDS	ENST00000485957	ENST00000469044	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-3CDS	ENST00000485957	ENST00000491704	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000358441	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000489213	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000461822	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000485396	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000471453	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000470821	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000393058	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+
5UTR-intron	ENST00000485957	ENST00000538260	MECOM	chr3	169098975	-	ARMC8	chr3	138007890	+

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FusionProtFeatures for MECOM_ARMC8

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MECOM Q03112	ARMC8 Q8IUR7

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Fusion gene ID: 21419

FusionGeneSummary for MECOM_ARMC8

FusionProtFeatures for MECOM_ARMC8