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Fusion gene ID: 21385

FusionGeneSummary for MDM2_FMO6P

Fusion gene summary

Fusion gene information	Fusion gene name: MDM2_FMO6P
	Fusion gene ID: 21385
		Hgene	Tgene
	Gene symbol	MDM2	FMO6P
	Gene ID	4193	388714
	Gene name	MDM2 proto-oncogene	flavin containing monooxygenase 6 pseudogene
	Synonyms	ACTFS\|HDMX\|hdm2	FMO6
	Cytomap	12q15	1q24.3
	Type of gene	protein-coding	pseudo
	Description	E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum	novel flavin containing monooxygenase
	Modification date	20180527	20180329
	UniProtAcc	Q00987	O60774
	Ensembl transtripts involved in fusion gene	ENST00000462284, ENST00000356290, ENST00000540827, ENST00000258149, ENST00000428863, ENST00000393412, ENST00000258148, ENST00000544561, ENST00000393410, ENST00000393413, ENST00000517852, ENST00000545204, ENST00000350057, ENST00000360430, ENST00000299252, ENST00000348801, ENST00000478070, ENST00000544125,	ENST00000236166,
Fusion gene scores	* DoF score	24 X 14 X 8=2688	1 X 1 X 1=1
	# samples	25	1
	** MAII score	log2(25/2688*10)=-3.42653313811667 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: MDM2 [Title/Abstract] AND FMO6P [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MDM2	GO:0000122	negative regulation of transcription by RNA polymerase II	9271120\|17310983
Hgene	MDM2	GO:0006511	ubiquitin-dependent protein catabolic process	11278372\|15314173\|16173922\|17310983
Hgene	MDM2	GO:0016567	protein ubiquitination	9450543\|15878855\|19656744\|20153724
Hgene	MDM2	GO:0031648	protein destabilization	9529249\|10360174\|15314173
Hgene	MDM2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11278372
Hgene	MDM2	GO:0034504	protein localization to nucleus	10360174
Hgene	MDM2	GO:0042176	regulation of protein catabolic process	9153395
Hgene	MDM2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	9529249\|10360174
Hgene	MDM2	GO:0045184	establishment of protein localization	10360174
Hgene	MDM2	GO:0045892	negative regulation of transcription, DNA-templated	9271120
Hgene	MDM2	GO:0065003	protein-containing complex assembly	10608892\|12915590
Hgene	MDM2	GO:0071157	negative regulation of cell cycle arrest	9529249
Hgene	MDM2	GO:0071480	cellular response to gamma radiation	16213212
Hgene	MDM2	GO:0072717	cellular response to actinomycin D	15314173
Hgene	MDM2	GO:1901797	negative regulation of signal transduction by p53 class mediator	16173922

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SARC	TCGA-DX-A1L3-01A	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000462284	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000356290	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000540827	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000258149	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000428863	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000393412	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000258148	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000544561	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000393410	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000393413	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000517852	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000545204	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000350057	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000360430	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000299252	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
In-frame	ENST00000348801	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000478070	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+
intron-3CDS	ENST00000544125	ENST00000236166	MDM2	chr12	69229764	+	FMO6P	chr1	171112320	+

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FusionProtFeatures for MDM2_FMO6P

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MDM2 Q00987	FMO6P O60774

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Fusion gene ID: 21385

FusionGeneSummary for MDM2_FMO6P

FusionProtFeatures for MDM2_FMO6P