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Fusion gene ID: 21380 |
FusionGeneSummary for MDM2_COMMD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MDM2_COMMD2 | Fusion gene ID: 21380 | Hgene | Tgene | Gene symbol | MDM2 | COMMD2 | Gene ID | 4193 | 51122 |
| Gene name | MDM2 proto-oncogene | COMM domain containing 2 | |
| Synonyms | ACTFS|HDMX|hdm2 | HSPC042 | |
| Cytomap | 12q15 | 3q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum | COMM domain-containing protein 2 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q00987 | Q86X83 | |
| Ensembl transtripts involved in fusion gene | ENST00000462284, ENST00000356290, ENST00000540827, ENST00000258149, ENST00000428863, ENST00000393412, ENST00000258148, ENST00000544561, ENST00000393410, ENST00000393413, ENST00000517852, ENST00000545204, ENST00000350057, ENST00000360430, ENST00000299252, ENST00000348801, ENST00000478070, ENST00000544125, | ENST00000473414, | |
| Fusion gene scores | * DoF score | 24 X 14 X 8=2688 | 3 X 3 X 2=18 |
| # samples | 25 | 3 | |
| ** MAII score | log2(25/2688*10)=-3.42653313811667 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MDM2 [Title/Abstract] AND COMMD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MDM2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9271120|17310983 |
| Hgene | MDM2 | GO:0006511 | ubiquitin-dependent protein catabolic process | 11278372|15314173|16173922|17310983 |
| Hgene | MDM2 | GO:0016567 | protein ubiquitination | 9450543|15878855|19656744|20153724 |
| Hgene | MDM2 | GO:0031648 | protein destabilization | 9529249|10360174|15314173 |
| Hgene | MDM2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 11278372 |
| Hgene | MDM2 | GO:0034504 | protein localization to nucleus | 10360174 |
| Hgene | MDM2 | GO:0042176 | regulation of protein catabolic process | 9153395 |
| Hgene | MDM2 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 9529249|10360174 |
| Hgene | MDM2 | GO:0045184 | establishment of protein localization | 10360174 |
| Hgene | MDM2 | GO:0045892 | negative regulation of transcription, DNA-templated | 9271120 |
| Hgene | MDM2 | GO:0065003 | protein-containing complex assembly | 10608892|12915590 |
| Hgene | MDM2 | GO:0071157 | negative regulation of cell cycle arrest | 9529249 |
| Hgene | MDM2 | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Hgene | MDM2 | GO:0072717 | cellular response to actinomycin D | 15314173 |
| Hgene | MDM2 | GO:1901797 | negative regulation of signal transduction by p53 class mediator | 16173922 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ223057 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000462284 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000356290 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000540827 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| 5CDS-3UTR | ENST00000258149 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000428863 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000393412 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| 5CDS-3UTR | ENST00000258148 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000544561 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000393410 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000393413 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000517852 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000545204 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| 5CDS-3UTR | ENST00000350057 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000360430 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000299252 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000348801 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000478070 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
| intron-3UTR | ENST00000544125 | ENST00000473414 | MDM2 | chr12 | 69222637 | + | COMMD2 | chr3 | 149458898 | - |
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FusionProtFeatures for MDM2_COMMD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MDM2 | COMMD2 |