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Fusion gene ID: 21372 |
FusionGeneSummary for MDM1_NAV3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MDM1_NAV3 | Fusion gene ID: 21372 | Hgene | Tgene | Gene symbol | MDM1 | NAV3 | Gene ID | 56890 | 89795 |
| Gene name | Mdm1 nuclear protein | neuron navigator 3 | |
| Synonyms | - | POMFIL1|STEERIN3|unc53H3 | |
| Cytomap | 12q15 | 12q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear protein MDM1Mdm4, transformed 3T3 cell double minute 1, p53 binding proteinnuclear protein double minute 1 | neuron navigator 3pore membrane and/or filament interacting like protein 1unc-53 homolog 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TC05 | Q8IVL0 | |
| Ensembl transtripts involved in fusion gene | ENST00000540418, ENST00000303145, ENST00000411698, ENST00000393543, ENST00000430606, ENST00000545724, | ENST00000536525, ENST00000397909, ENST00000228327, ENST00000266692, ENST00000552300, ENST00000541270, | |
| Fusion gene scores | * DoF score | 8 X 6 X 3=144 | 15 X 13 X 4=780 |
| # samples | 7 | 11 | |
| ** MAII score | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/780*10)=-2.82597060022495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MDM1 [Title/Abstract] AND NAV3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A2J0-01A | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000540418 | ENST00000536525 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000540418 | ENST00000397909 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000540418 | ENST00000228327 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000540418 | ENST00000266692 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-intron | ENST00000540418 | ENST00000552300 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-intron | ENST00000540418 | ENST00000541270 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000303145 | ENST00000536525 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000303145 | ENST00000397909 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000303145 | ENST00000228327 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000303145 | ENST00000266692 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5CDS-intron | ENST00000303145 | ENST00000552300 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5CDS-intron | ENST00000303145 | ENST00000541270 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000411698 | ENST00000536525 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000411698 | ENST00000397909 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000411698 | ENST00000228327 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| Frame-shift | ENST00000411698 | ENST00000266692 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5CDS-intron | ENST00000411698 | ENST00000552300 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5CDS-intron | ENST00000411698 | ENST00000541270 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000393543 | ENST00000536525 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000393543 | ENST00000397909 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000393543 | ENST00000228327 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000393543 | ENST00000266692 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-intron | ENST00000393543 | ENST00000552300 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-intron | ENST00000393543 | ENST00000541270 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000430606 | ENST00000536525 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000430606 | ENST00000397909 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000430606 | ENST00000228327 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-3CDS | ENST00000430606 | ENST00000266692 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-intron | ENST00000430606 | ENST00000552300 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| intron-intron | ENST00000430606 | ENST00000541270 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5UTR-3CDS | ENST00000545724 | ENST00000536525 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5UTR-3CDS | ENST00000545724 | ENST00000397909 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5UTR-3CDS | ENST00000545724 | ENST00000228327 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5UTR-3CDS | ENST00000545724 | ENST00000266692 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5UTR-intron | ENST00000545724 | ENST00000552300 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
| 5UTR-intron | ENST00000545724 | ENST00000541270 | MDM1 | chr12 | 68720437 | - | NAV3 | chr12 | 78594253 | + |
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FusionProtFeatures for MDM1_NAV3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MDM1 | NAV3 |