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Fusion gene ID: 21263 |
FusionGeneSummary for MCCC1_MED10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MCCC1_MED10 | Fusion gene ID: 21263 | Hgene | Tgene | Gene symbol | MCCC1 | MED10 | Gene ID | 56922 | 84246 |
| Gene name | methylcrotonoyl-CoA carboxylase 1 | mediator complex subunit 10 | |
| Synonyms | MCC-B|MCCA | L6|NUT2|TRG20 | |
| Cytomap | 3q27.1 | 5p15.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial3-methylcrotonyl-CoA carboxylase 13-methylcrotonyl-CoA carboxylase biotin-containing subunit3-methylcrotonyl-CoA:carbon dioxide ligase subunit alphaMCCase subunit alphamethylcrotonoyl-CoA ca | mediator of RNA polymerase II transcription subunit 10TRG-17TRG-20mediator of RNA polymerase II transcription, subunit 10transformation-related gene 17 proteintransformation-related gene 20 protein | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96RQ3 | Q9BTT4 | |
| Ensembl transtripts involved in fusion gene | ENST00000265594, ENST00000492597, ENST00000539926, ENST00000489909, | ENST00000255764, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 4 X 3 X 2=24 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MCCC1 [Title/Abstract] AND MED10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A1LI-01A | MCCC1 | chr3 | 182788787 | - | MED10 | chr5 | 6372714 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000265594 | ENST00000255764 | MCCC1 | chr3 | 182788787 | - | MED10 | chr5 | 6372714 | - |
| Frame-shift | ENST00000492597 | ENST00000255764 | MCCC1 | chr3 | 182788787 | - | MED10 | chr5 | 6372714 | - |
| Frame-shift | ENST00000539926 | ENST00000255764 | MCCC1 | chr3 | 182788787 | - | MED10 | chr5 | 6372714 | - |
| intron-3CDS | ENST00000489909 | ENST00000255764 | MCCC1 | chr3 | 182788787 | - | MED10 | chr5 | 6372714 | - |
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FusionProtFeatures for MCCC1_MED10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MCCC1 | MED10 |