|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 21238 |
FusionGeneSummary for MBP_SWAP70 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MBP_SWAP70 | Fusion gene ID: 21238 | Hgene | Tgene | Gene symbol | MBP | SWAP70 | Gene ID | 5553 | 23075 |
| Gene name | proteoglycan 2, pro eosinophil major basic protein | switching B cell complex subunit SWAP70 | |
| Synonyms | BMPG|MBP|MBP1|proMBP | HSPC321|SWAP-70 | |
| Cytomap | 11q12.1 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | switch-associated protein 70SWAP switching B-cell complex 70kDa subunitSWAP switching B-cell complex subunit 70 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P02686 | Q9UH65 | |
| Ensembl transtripts involved in fusion gene | ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778, | ENST00000447399, ENST00000318950, | |
| Fusion gene scores | * DoF score | 13 X 13 X 3=507 | 1 X 1 X 1=1 |
| # samples | 15 | 1 | |
| ** MAII score | log2(15/507*10)=-1.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MBP [Title/Abstract] AND SWAP70 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA436904 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000382582 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000382582 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000355994 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000355994 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397875 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397875 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397866 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397866 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397865 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397865 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000527041 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000527041 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000359645 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000359645 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000528160 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000528160 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397869 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397869 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000354542 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000354542 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000526111 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000526111 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000580402 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000580402 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000579129 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000579129 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000578193 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000578193 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397863 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397863 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397860 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000397860 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000487778 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
| intron-3CDS | ENST00000487778 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
Top |
FusionProtFeatures for MBP_SWAP70 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MBP | SWAP70 |