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Fusion gene ID: 21227

FusionGeneSummary for MBP_ALMS1

Fusion gene summary

Fusion gene information	Fusion gene name: MBP_ALMS1
	Fusion gene ID: 21227
		Hgene	Tgene
	Gene symbol	MBP	ALMS1
	Gene ID	5553	7840
	Gene name	proteoglycan 2, pro eosinophil major basic protein	ALMS1, centrosome and basal body associated protein
	Synonyms	BMPG\|MBP\|MBP1\|proMBP	ALSS
	Cytomap	11q12.1	2p13.1
	Type of gene	protein-coding	protein-coding
	Description	bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	Alstrom syndrome protein 1Alstrom syndrome 1
	Modification date	20180519	20180523
	UniProtAcc	P02686	Q8TCU4
	Ensembl transtripts involved in fusion gene	ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778,	ENST00000377715, ENST00000409009, ENST00000264448, ENST00000464408,
Fusion gene scores	* DoF score	13 X 13 X 3=507	3 X 2 X 3=18
	# samples	15	5
	** MAII score	log2(15/507*10)=-1.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MBP [Title/Abstract] AND ALMS1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AV724910	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
ChiTaRS3.1			AV722334	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
ChiTaRS3.1			AV723294	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000382582	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000382582	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000382582	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000382582	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
5CDS-intron	ENST00000355994	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
5CDS-intron	ENST00000355994	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
5CDS-intron	ENST00000355994	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
5CDS-intron	ENST00000355994	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397875	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397875	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397875	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397875	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397866	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397866	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397866	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397866	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397865	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397865	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397865	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397865	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000527041	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000527041	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000527041	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000527041	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000359645	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000359645	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000359645	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000359645	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000528160	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000528160	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000528160	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000528160	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397869	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397869	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397869	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397869	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000354542	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000354542	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000354542	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000354542	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000526111	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000526111	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000526111	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000526111	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000580402	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000580402	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000580402	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000580402	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000579129	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000579129	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000579129	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000579129	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000578193	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000578193	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000578193	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000578193	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397863	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397863	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397863	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397863	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397860	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397860	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397860	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000397860	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000487778	ENST00000377715	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000487778	ENST00000409009	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000487778	ENST00000264448	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-
intron-intron	ENST00000487778	ENST00000464408	MBP	chr18	74690794	-	ALMS1	chr2	73823368	-

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FusionProtFeatures for MBP_ALMS1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MBP P02686	ALMS1 Q8TCU4

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Fusion gene ID: 21227

FusionGeneSummary for MBP_ALMS1

FusionProtFeatures for MBP_ALMS1