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Fusion gene ID: 21210 |
FusionGeneSummary for MBOAT1_DCDC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MBOAT1_DCDC2 | Fusion gene ID: 21210 | Hgene | Tgene | Gene symbol | MBOAT1 | DCDC2 | Gene ID | 154141 | 51473 |
| Gene name | membrane bound O-acyltransferase domain containing 1 | doublecortin domain containing 2 | |
| Synonyms | LPEAT1|LPLAT|LPLAT 1|LPSAT|OACT1|dJ434O11.1 | DCDC2A|DFNB66|NPHP19|NSC|RU2|RU2S | |
| Cytomap | 6p22.3 | 6p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysophospholipid acyltransferase 11-acylglycerophosphoserine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 1O-acyltransferase domain-containing protein 1lyso-PS acyltransferaselysophosphatidylethanolamine acyltransferase 1lys | doublecortin domain-containing protein 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6ZNC8 | Q9UHG0 | |
| Ensembl transtripts involved in fusion gene | ENST00000541730, ENST00000324607, ENST00000536798, | ENST00000378454, ENST00000378450, | |
| Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 9 X 5 X 8=360 |
| # samples | 8 | 11 | |
| ** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MBOAT1 [Title/Abstract] AND DCDC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-GV-A3QH-01A | MBOAT1 | chr6 | 20126748 | - | DCDC2 | chr6 | 24302272 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000541730 | ENST00000378454 | MBOAT1 | chr6 | 20126748 | - | DCDC2 | chr6 | 24302272 | - |
| 5CDS-intron | ENST00000541730 | ENST00000378450 | MBOAT1 | chr6 | 20126748 | - | DCDC2 | chr6 | 24302272 | - |
| In-frame | ENST00000324607 | ENST00000378454 | MBOAT1 | chr6 | 20126748 | - | DCDC2 | chr6 | 24302272 | - |
| 5CDS-intron | ENST00000324607 | ENST00000378450 | MBOAT1 | chr6 | 20126748 | - | DCDC2 | chr6 | 24302272 | - |
| In-frame | ENST00000536798 | ENST00000378454 | MBOAT1 | chr6 | 20126748 | - | DCDC2 | chr6 | 24302272 | - |
| 5CDS-intron | ENST00000536798 | ENST00000378450 | MBOAT1 | chr6 | 20126748 | - | DCDC2 | chr6 | 24302272 | - |
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FusionProtFeatures for MBOAT1_DCDC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MBOAT1 | DCDC2 |