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Fusion gene ID: 21191 |
FusionGeneSummary for MBD6_MYH14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MBD6_MYH14 | Fusion gene ID: 21191 | Hgene | Tgene | Gene symbol | MBD6 | MYH14 | Gene ID | 114785 | 79784 |
| Gene name | methyl-CpG binding domain protein 6 | myosin heavy chain 14 | |
| Synonyms | - | DFNA4|DFNA4A|FP17425|MHC16|MYH17|NMHC II-C|NMHC-II-C|PNMHH|myosin | |
| Cytomap | 12q13.3 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyl-CpG-binding domain protein 6methyl-CpG-binding protein MBD6 | myosin-14MYH14 variant proteinmyosin heavy chain, non-muscle IIcmyosin, heavy chain 14, non-musclemyosin, heavy polypeptide 14non-muscle myosin heavy chain IIcnonmuscle myosin heavy chain II-C | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96DN6 | Q7Z406 | |
| Ensembl transtripts involved in fusion gene | ENST00000549231, ENST00000355673, ENST00000431731, | ENST00000598205, ENST00000376970, ENST00000425460, ENST00000440075, ENST00000601313, ENST00000262269, ENST00000596571, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 7 X 8 X 6=336 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MBD6 [Title/Abstract] AND MYH14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MYH14 | GO:0031032 | actomyosin structure organization | 24072716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW362436 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000549231 | ENST00000598205 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| intron-intron | ENST00000549231 | ENST00000376970 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| intron-intron | ENST00000549231 | ENST00000425460 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| intron-intron | ENST00000549231 | ENST00000440075 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| intron-intron | ENST00000549231 | ENST00000601313 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| intron-intron | ENST00000549231 | ENST00000262269 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| intron-intron | ENST00000549231 | ENST00000596571 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000355673 | ENST00000598205 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000355673 | ENST00000376970 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000355673 | ENST00000425460 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000355673 | ENST00000440075 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000355673 | ENST00000601313 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000355673 | ENST00000262269 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000355673 | ENST00000596571 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000431731 | ENST00000598205 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000431731 | ENST00000376970 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000431731 | ENST00000425460 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000431731 | ENST00000440075 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000431731 | ENST00000601313 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000431731 | ENST00000262269 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
| 3UTR-intron | ENST00000431731 | ENST00000596571 | MBD6 | chr12 | 57923765 | + | MYH14 | chr19 | 50808382 | + |
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FusionProtFeatures for MBD6_MYH14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MBD6 | MYH14 |