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Fusion gene ID: 21169

FusionGeneSummary for MAX_FGR

Fusion gene summary

Fusion gene information	Fusion gene name: MAX_FGR
	Fusion gene ID: 21169
		Hgene	Tgene
	Gene symbol	MAX	FGR
	Gene ID	4149	2268
	Gene name	MYC associated factor X	FGR proto-oncogene, Src family tyrosine kinase
	Synonyms	bHLHd4	SRC2\|c-fgr\|c-src2\|p55-Fgr\|p55c-fgr\|p58-Fgr\|p58c-fgr
	Cytomap	14q23.3	1p35.3
	Type of gene	protein-coding	protein-coding
	Description	protein maxclass D basic helix-loop-helix protein 4	tyrosine-protein kinase FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologc-fgr protooncogenec-src-2 proto-oncogenefeline Gardner-Rasheed sarcoma viral oncogene homologp55-c-fgr proteinproto-oncogene c-Fgrproto-oncogene tyrosine-prote
	Modification date	20180523	20180523
	UniProtAcc	P61244	P09769
	Ensembl transtripts involved in fusion gene	ENST00000341653, ENST00000358402, ENST00000555932, ENST00000284165, ENST00000358664, ENST00000555419, ENST00000557277, ENST00000556979, ENST00000555667, ENST00000557746, ENST00000556443, ENST00000246163,	ENST00000374005, ENST00000399173, ENST00000545953, ENST00000374004, ENST00000468038,
Fusion gene scores	* DoF score	4 X 2 X 4=32	4 X 5 X 7=140
	# samples	4	11
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(11/140*10)=-0.347923303420307 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAX [Title/Abstract] AND FGR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAX	GO:0000122	negative regulation of transcription by RNA polymerase II	8521822
Tgene	FGR	GO:0018108	peptidyl-tyrosine phosphorylation	7519620\|8327512
Tgene	FGR	GO:0046777	protein autophosphorylation	2181286\|8327512

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BI031363	MAX	chr14	65545992	-	FGR	chr1	27939823	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000341653	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000341653	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000341653	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000341653	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000341653	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358402	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358402	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358402	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358402	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000358402	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555932	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555932	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555932	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555932	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000555932	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000284165	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000284165	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000284165	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000284165	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000284165	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358664	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358664	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358664	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000358664	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000358664	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555419	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555419	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555419	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555419	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000555419	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557277	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557277	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557277	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557277	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000557277	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556979	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556979	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556979	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556979	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000556979	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555667	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555667	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555667	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000555667	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000555667	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557746	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557746	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557746	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000557746	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000557746	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556443	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556443	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556443	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000556443	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000556443	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000246163	ENST00000374005	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000246163	ENST00000399173	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000246163	ENST00000545953	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-3CDS	ENST00000246163	ENST00000374004	MAX	chr14	65545992	-	FGR	chr1	27939823	+
intron-intron	ENST00000246163	ENST00000468038	MAX	chr14	65545992	-	FGR	chr1	27939823	+

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FusionProtFeatures for MAX_FGR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAX P61244	FGR P09769

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Fusion gene ID: 21169

FusionGeneSummary for MAX_FGR

FusionProtFeatures for MAX_FGR