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Fusion gene ID: 21107 |
FusionGeneSummary for MARVELD2_WDR19 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MARVELD2_WDR19 | Fusion gene ID: 21107 | Hgene | Tgene | Gene symbol | MARVELD2 | WDR19 | Gene ID | 153562 | 57728 |
| Gene name | MARVEL domain containing 2 | WD repeat domain 19 | |
| Synonyms | DFNB49|MARVD2|MRVLDC2|Tric | ATD5|CED4|DYF-2|IFT144|NPHP13|ORF26|Oseg6|PWDMP|SRTD5 | |
| Cytomap | 5q13.2 | 4p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MARVEL domain-containing protein 2MARVEL (membrane-associating) domain containing 2tricellulin | WD repeat-containing protein 19WD repeat membrane protein PWDMPintraflagellar transport 144 homolog | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q8N4S9 | Q8NEZ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000325631, ENST00000413223, | ENST00000399820, ENST00000288634, ENST00000506503, ENST00000515631, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 4=64 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MARVELD2 [Title/Abstract] AND WDR19 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-62-A46V-01A | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000325631 | ENST00000399820 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| 5CDS-3UTR | ENST00000325631 | ENST00000288634 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| 5CDS-intron | ENST00000325631 | ENST00000506503 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| 5CDS-intron | ENST00000325631 | ENST00000515631 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| 5CDS-3UTR | ENST00000413223 | ENST00000399820 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| 5CDS-3UTR | ENST00000413223 | ENST00000288634 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| 5CDS-intron | ENST00000413223 | ENST00000506503 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
| 5CDS-intron | ENST00000413223 | ENST00000515631 | MARVELD2 | chr5 | 68716358 | + | WDR19 | chr4 | 39287107 | + |
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FusionProtFeatures for MARVELD2_WDR19 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MARVELD2 | WDR19 |