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Fusion gene ID: 21044 |
FusionGeneSummary for MAPKBP1_EPB42 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPKBP1_EPB42 | Fusion gene ID: 21044 | Hgene | Tgene | Gene symbol | MAPKBP1 | EPB42 | Gene ID | 23005 | 2038 |
| Gene name | mitogen-activated protein kinase binding protein 1 | erythrocyte membrane protein band 4.2 | |
| Synonyms | JNKBP-1|JNKBP1|NPHP20 | PA|SPH5 | |
| Cytomap | 15q15.1 | 15q15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase-binding protein 1JNK-binding protein 1 | erythrocyte membrane protein band 4.2P4.2erythrocyte protein 4.2erythrocyte surface protein band 4.2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O60336 | P16452 | |
| Ensembl transtripts involved in fusion gene | ENST00000221214, ENST00000457542, ENST00000260357, ENST00000456763, ENST00000514566, ENST00000507762, | ENST00000563128, ENST00000300215, ENST00000540029, ENST00000441366, | |
| Fusion gene scores | * DoF score | 7 X 4 X 3=84 | 3 X 2 X 3=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/84*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAPKBP1 [Title/Abstract] AND EPB42 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | MESO | TCGA-3H-AB3M-01A | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000221214 | ENST00000563128 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000221214 | ENST00000300215 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000221214 | ENST00000540029 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000221214 | ENST00000441366 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000457542 | ENST00000563128 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000457542 | ENST00000300215 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000457542 | ENST00000540029 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000457542 | ENST00000441366 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5UTR-5UTR | ENST00000260357 | ENST00000563128 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5UTR-5UTR | ENST00000260357 | ENST00000300215 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5UTR-5UTR | ENST00000260357 | ENST00000540029 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5UTR-5UTR | ENST00000260357 | ENST00000441366 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000456763 | ENST00000563128 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000456763 | ENST00000300215 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000456763 | ENST00000540029 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000456763 | ENST00000441366 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000514566 | ENST00000563128 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000514566 | ENST00000300215 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000514566 | ENST00000540029 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 5CDS-5UTR | ENST00000514566 | ENST00000441366 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 3UTR-5UTR | ENST00000507762 | ENST00000563128 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 3UTR-5UTR | ENST00000507762 | ENST00000300215 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 3UTR-5UTR | ENST00000507762 | ENST00000540029 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
| 3UTR-5UTR | ENST00000507762 | ENST00000441366 | MAPKBP1 | chr15 | 42067587 | + | EPB42 | chr15 | 43495473 | - |
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FusionProtFeatures for MAPKBP1_EPB42 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPKBP1 | EPB42 |