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Fusion gene ID: 21040 |
FusionGeneSummary for MAPKAPK5_TRAFD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPKAPK5_TRAFD1 | Fusion gene ID: 21040 | Hgene | Tgene | Gene symbol | MAPKAPK5 | TRAFD1 | Gene ID | 8550 | 10906 |
| Gene name | mitogen-activated protein kinase-activated protein kinase 5 | TRAF-type zinc finger domain containing 1 | |
| Synonyms | MAPKAP-K5|MK-5|MK5|PRAK | FLN29 | |
| Cytomap | 12q24.12-q24.13 | 12q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAP kinase-activated protein kinase 5MAPK-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5p38-regulated/activated protein kinase | TRAF-type zinc finger domain-containing protein 1FLN29 gene product | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8IW41 | O14545 | |
| Ensembl transtripts involved in fusion gene | ENST00000550735, ENST00000551404, ENST00000547305, ENST00000546394, | ENST00000412615, ENST00000257604, | |
| Fusion gene scores | * DoF score | 8 X 8 X 7=448 | 3 X 4 X 3=36 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/448*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAPKAPK5 [Title/Abstract] AND TRAFD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPKAPK5 | GO:0006417 | regulation of translation | 21329882 |
| Hgene | MAPKAPK5 | GO:0007265 | Ras protein signal transduction | 17254968 |
| Hgene | MAPKAPK5 | GO:0046777 | protein autophosphorylation | 21329882 |
| Hgene | MAPKAPK5 | GO:0090400 | stress-induced premature senescence | 17254968 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-L5-A4OT-01A | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000550735 | ENST00000412615 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| 5CDS-5UTR | ENST00000550735 | ENST00000257604 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| 5CDS-5UTR | ENST00000551404 | ENST00000412615 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| 5CDS-5UTR | ENST00000551404 | ENST00000257604 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| intron-5UTR | ENST00000547305 | ENST00000412615 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| intron-5UTR | ENST00000547305 | ENST00000257604 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| intron-5UTR | ENST00000546394 | ENST00000412615 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
| intron-5UTR | ENST00000546394 | ENST00000257604 | MAPKAPK5 | chr12 | 112308984 | + | TRAFD1 | chr12 | 112568315 | + |
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FusionProtFeatures for MAPKAPK5_TRAFD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPKAPK5 | TRAFD1 |