	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 21021

FusionGeneSummary for MAPK9_S100A6

Fusion gene summary

Fusion gene information	Fusion gene name: MAPK9_S100A6
	Fusion gene ID: 21021
		Hgene	Tgene
	Gene symbol	MAPK9	S100A6
	Gene ID	5601	6277
	Gene name	mitogen-activated protein kinase 9	S100 calcium binding protein A6
	Synonyms	JNK-55\|JNK2\|JNK2A\|JNK2ALPHA\|JNK2B\|JNK2BETA\|PRKM9\|SAPK\|SAPK1a\|p54a\|p54aSAPK	2A9\|5B10\|CABP\|CACY\|PRA\|S10A6
	Cytomap	5q35.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase 9Jun kinaseMAP kinase 9MAPK 9c-Jun N-terminal kinase 2c-Jun kinase 2stress-activated protein kinase 1astress-activated protein kinase JNK2	protein S100-A6MLN 4calcyclingrowth factor-inducible protein 2A9prolactin receptor-associated protein
	Modification date	20180523	20180522
	UniProtAcc	P45984	P06703
	Ensembl transtripts involved in fusion gene	ENST00000452135, ENST00000393360, ENST00000455781, ENST00000343111, ENST00000347470, ENST00000397072, ENST00000425491, ENST00000539014, ENST00000524170,	ENST00000496817, ENST00000368719, ENST00000368720,
Fusion gene scores	* DoF score	5 X 6 X 3=90	4 X 4 X 1=16
	# samples	9	5
	** MAII score	log2(9/90*10)=0	log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MAPK9 [Title/Abstract] AND S100A6 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAPK9	GO:0007254	JNK cascade	8654373
Hgene	MAPK9	GO:0018105	peptidyl-serine phosphorylation	21856198

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BI963166	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000452135	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000452135	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000452135	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000393360	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000393360	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000393360	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000455781	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000455781	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000455781	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000343111	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000343111	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000343111	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000347470	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000347470	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000347470	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000397072	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000397072	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000397072	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000425491	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000425491	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000425491	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000539014	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000539014	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000539014	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000524170	ENST00000496817	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000524170	ENST00000368719	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+
intron-3CDS	ENST00000524170	ENST00000368720	MAPK9	chr5	179660683	+	S100A6	chr1	153507760	+

Top

FusionProtFeatures for MAPK9_S100A6

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAPK9 P45984	S100A6 P06703

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 21021

FusionGeneSummary for MAPK9_S100A6

FusionProtFeatures for MAPK9_S100A6