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Fusion gene ID: 20997 |
FusionGeneSummary for MAPK1_YDJC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPK1_YDJC | Fusion gene ID: 20997 | Hgene | Tgene | Gene symbol | MAPK1 | YDJC | Gene ID | 5594 | 150223 |
| Gene name | mitogen-activated protein kinase 1 | YdjC chitooligosaccharide deacetylase homolog | |
| Synonyms | ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK | - | |
| Cytomap | 22q11.22 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2 | carbohydrate deacetylaseUPF0249 protein ydjC homologYdjC homolog | |
| Modification date | 20180529 | 20180519 | |
| UniProtAcc | P28482 | A8MPS7 | |
| Ensembl transtripts involved in fusion gene | ENST00000215832, ENST00000398822, ENST00000544786, ENST00000491588, | ENST00000292778, ENST00000398873, | |
| Fusion gene scores | * DoF score | 18 X 13 X 10=2340 | 1 X 1 X 1=1 |
| # samples | 23 | 1 | |
| ** MAII score | log2(23/2340*10)=-3.34680276352639 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MAPK1 [Title/Abstract] AND YDJC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPK1 | GO:0006468 | protein phosphorylation | 23184662 |
| Hgene | MAPK1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16314496 |
| Hgene | MAPK1 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| Hgene | MAPK1 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
| Hgene | MAPK1 | GO:0038127 | ERBB signaling pathway | 15133037 |
| Hgene | MAPK1 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
| Hgene | MAPK1 | GO:0070371 | ERK1 and ERK2 cascade | 16314496 |
| Hgene | MAPK1 | GO:0070849 | response to epidermal growth factor | 18794356 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AC-A8OQ-01A | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000215832 | ENST00000292778 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| In-frame | ENST00000215832 | ENST00000398873 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| In-frame | ENST00000398822 | ENST00000292778 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| In-frame | ENST00000398822 | ENST00000398873 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| In-frame | ENST00000544786 | ENST00000292778 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| In-frame | ENST00000544786 | ENST00000398873 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| intron-3CDS | ENST00000491588 | ENST00000292778 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
| intron-3CDS | ENST00000491588 | ENST00000398873 | MAPK1 | chr22 | 22221612 | - | YDJC | chr22 | 21983696 | - |
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FusionProtFeatures for MAPK1_YDJC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK1 | YDJC |