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Fusion gene ID: 2099 |
FusionGeneSummary for AP3S1_ARL14EPL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AP3S1_ARL14EPL | Fusion gene ID: 2099 | Hgene | Tgene | Gene symbol | AP3S1 | ARL14EPL | Gene ID | 1176 | 644100 |
| Gene name | adaptor related protein complex 3 subunit sigma 1 | ADP ribosylation factor like GTPase 14 effector protein like | |
| Synonyms | CLAPS3|Sigma3A | - | |
| Cytomap | 5q22.3-q23.1 | 5q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP-3 complex subunit sigma-1adapter-related protein complex 3 subunit sigma-1adaptor related protein complex 3 sigma 1 subunitclathrin adaptor complex AP3, sigma-3A subunitclathrin-associated/assembly/adapter protein, small 3clathrin-associated/assem | ARL14 effector protein-likeADP-ribosylation factor-like 14 effector protein-like | |
| Modification date | 20180519 | 20180409 | |
| UniProtAcc | Q92572 | P0DKL9 | |
| Ensembl transtripts involved in fusion gene | ENST00000316788, ENST00000505423, | ENST00000601302, | |
| Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: AP3S1 [Title/Abstract] AND ARL14EPL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HC-7818-01A | AP3S1 | chr5 | 115177803 | + | ARL14EPL | chr5 | 115389711 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000316788 | ENST00000601302 | AP3S1 | chr5 | 115177803 | + | ARL14EPL | chr5 | 115389711 | + |
| intron-3CDS | ENST00000505423 | ENST00000601302 | AP3S1 | chr5 | 115177803 | + | ARL14EPL | chr5 | 115389711 | + |
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FusionProtFeatures for AP3S1_ARL14EPL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AP3S1 | ARL14EPL |