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Fusion gene ID: 20965 |
FusionGeneSummary for MAPK10_INPP4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPK10_INPP4B | Fusion gene ID: 20965 | Hgene | Tgene | Gene symbol | MAPK10 | INPP4B | Gene ID | 5602 | 8821 |
| Gene name | mitogen-activated protein kinase 10 | inositol polyphosphate-4-phosphatase type II B | |
| Synonyms | JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK | - | |
| Cytomap | 4q21.3 | 4q31.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3 | type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa | |
| Modification date | 20180524 | 20180523 | |
| UniProtAcc | P53779 | O15327 | |
| Ensembl transtripts involved in fusion gene | ENST00000395169, ENST00000359221, ENST00000361569, ENST00000395166, ENST00000449047, ENST00000395161, ENST00000513839, ENST00000395157, ENST00000395160, | ENST00000513000, ENST00000509777, ENST00000262992, ENST00000308502, ENST00000508116, ENST00000507861, ENST00000506217, ENST00000508084, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 9 X 7 X 6=378 |
| # samples | 9 | 9 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAPK10 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP360877 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000395169 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395169 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395169 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395169 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395169 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395169 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395169 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395169 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000359221 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000359221 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000359221 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000359221 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000359221 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000359221 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000359221 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000359221 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000361569 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000361569 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000361569 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000361569 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000361569 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000361569 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000361569 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000361569 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395166 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395166 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395166 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395166 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395166 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395166 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395166 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395166 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000449047 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000449047 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000449047 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000449047 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000449047 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000449047 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000449047 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000449047 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395161 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395161 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395161 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395161 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000395161 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395161 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395161 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000395161 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000513839 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000513839 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000513839 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000513839 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-3CDS | ENST00000513839 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000513839 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000513839 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| 5UTR-intron | ENST00000513839 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395157 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395157 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395157 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395157 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395157 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-intron | ENST00000395157 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-intron | ENST00000395157 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-intron | ENST00000395157 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395160 | ENST00000513000 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395160 | ENST00000509777 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395160 | ENST00000262992 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395160 | ENST00000308502 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-3CDS | ENST00000395160 | ENST00000508116 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-intron | ENST00000395160 | ENST00000507861 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-intron | ENST00000395160 | ENST00000506217 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
| intron-intron | ENST00000395160 | ENST00000508084 | MAPK10 | chr4 | 87275682 | - | INPP4B | chr4 | 143067145 | - |
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FusionProtFeatures for MAPK10_INPP4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK10 | INPP4B |