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Fusion gene ID: 20959 |
FusionGeneSummary for MAP9_CACNB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP9_CACNB2 | Fusion gene ID: 20959 | Hgene | Tgene | Gene symbol | MAP9 | CACNB2 | Gene ID | 79884 | 783 |
| Gene name | microtubule associated protein 9 | calcium voltage-gated channel auxiliary subunit beta 2 | |
| Synonyms | ASAP | CACNLB2|CAVB2|MYSB | |
| Cytomap | 4q32.1 | 10p12.33-p12.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated protein 9aster-associated protein | voltage-dependent L-type calcium channel subunit beta-2CAB2calcium channel voltage-dependent subunit beta 2calcium channel, voltage-dependent, beta 2 subunitlambert-Eaton myasthenic syndrome antigen Bmyasthenic (Lambert-Eaton) syndrome antigen B | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q49MG5 | Q08289 | |
| Ensembl transtripts involved in fusion gene | ENST00000311277, ENST00000515654, ENST00000379248, | ENST00000324631, ENST00000377328, ENST00000352115, ENST00000282343, ENST00000377331, ENST00000396576, ENST00000377319, ENST00000377329, ENST00000377315, ENST00000467034, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 5 X 3=75 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAP9 [Title/Abstract] AND CACNB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP9 | GO:0090307 | mitotic spindle assembly | 16049101 |
| Tgene | CACNB2 | GO:0051928 | positive regulation of calcium ion transport | 1309651 |
| Tgene | CACNB2 | GO:0070509 | calcium ion import | 1309651 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA505169 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000311277 | ENST00000324631 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000377328 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000352115 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000282343 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000377331 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000396576 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000377319 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000377329 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000377315 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000311277 | ENST00000467034 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000324631 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000377328 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000352115 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000282343 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000377331 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000396576 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000377319 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000377329 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000377315 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000515654 | ENST00000467034 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000324631 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000377328 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000352115 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000282343 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000377331 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000396576 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000377319 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000377329 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000377315 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
| 5UTR-intron | ENST00000379248 | ENST00000467034 | MAP9 | chr4 | 156297921 | - | CACNB2 | chr10 | 18834460 | - |
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FusionProtFeatures for MAP9_CACNB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP9 | CACNB2 |