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Fusion gene ID: 20950 |
FusionGeneSummary for MAP7_CNKSR3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP7_CNKSR3 | Fusion gene ID: 20950 | Hgene | Tgene | Gene symbol | MAP7 | CNKSR3 | Gene ID | 9053 | 154043 |
| Gene name | microtubule associated protein 7 | CNKSR family member 3 | |
| Synonyms | E-MAP-115|EMAP115 | CNK3|CNK3/IPCEF1|MAGI1 | |
| Cytomap | 6q23.3 | 6q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ensconsinMAP-7dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))epithelial microtubule-associated protein of 115 kDa | connector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q14244 | Q6P9H4 | |
| Ensembl transtripts involved in fusion gene | ENST00000354570, ENST00000454590, ENST00000544465, ENST00000438100, ENST00000432797, | ENST00000607772, ENST00000479339, ENST00000433165, | |
| Fusion gene scores | * DoF score | 12 X 9 X 8=864 | 4 X 6 X 2=48 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/864*10)=-2.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAP7 [Title/Abstract] AND CNKSR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A0IQ-01A | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000354570 | ENST00000607772 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-5UTR | ENST00000354570 | ENST00000479339 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-intron | ENST00000354570 | ENST00000433165 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| In-frame | ENST00000454590 | ENST00000607772 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-5UTR | ENST00000454590 | ENST00000479339 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-intron | ENST00000454590 | ENST00000433165 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| In-frame | ENST00000544465 | ENST00000607772 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-5UTR | ENST00000544465 | ENST00000479339 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-intron | ENST00000544465 | ENST00000433165 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| In-frame | ENST00000438100 | ENST00000607772 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-5UTR | ENST00000438100 | ENST00000479339 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-intron | ENST00000438100 | ENST00000433165 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| Frame-shift | ENST00000432797 | ENST00000607772 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-5UTR | ENST00000432797 | ENST00000479339 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
| 5CDS-intron | ENST00000432797 | ENST00000433165 | MAP7 | chr6 | 136686873 | - | CNKSR3 | chr6 | 154771392 | - |
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FusionProtFeatures for MAP7_CNKSR3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP7 | CNKSR3 |