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Fusion gene ID: 20909 |
FusionGeneSummary for MAP4K5_ADCK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP4K5_ADCK1 | Fusion gene ID: 20909 | Hgene | Tgene | Gene symbol | MAP4K5 | ADCK1 | Gene ID | 11183 | 57143 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 5 | aarF domain containing kinase 1 | |
| Synonyms | GCKR|KHS|KHS1|MAPKKKK5 | - | |
| Cytomap | 14q22.1 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 5MAPK/ERK kinase kinase kinase 5MEK kinase kinase 5MEKKK 5germinal center kinase-relatedkinase homologous to SPS1/STE20 | uncharacterized aarF domain-containing protein kinase 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y4K4 | Q86TW2 | |
| Ensembl transtripts involved in fusion gene | ENST00000013125, ENST00000557578, | ENST00000238561, ENST00000341211, ENST00000556560, | |
| Fusion gene scores | * DoF score | 9 X 9 X 8=648 | 3 X 3 X 4=36 |
| # samples | 13 | 4 | |
| ** MAII score | log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAP4K5 [Title/Abstract] AND ADCK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K5 | GO:0006468 | protein phosphorylation | 9038372 |
| Hgene | MAP4K5 | GO:0035556 | intracellular signal transduction | 9038372 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAMW-01A | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000013125 | ENST00000238561 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| In-frame | ENST00000013125 | ENST00000341211 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| 5CDS-intron | ENST00000013125 | ENST00000556560 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| intron-3CDS | ENST00000557578 | ENST00000238561 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| intron-3CDS | ENST00000557578 | ENST00000341211 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| intron-intron | ENST00000557578 | ENST00000556560 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
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FusionProtFeatures for MAP4K5_ADCK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K5 | ADCK1 |