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Fusion gene ID: 20906 |
FusionGeneSummary for MAP4K4_REV1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP4K4_REV1 | Fusion gene ID: 20906 | Hgene | Tgene | Gene symbol | MAP4K4 | REV1 | Gene ID | 9448 | 51455 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 4 | REV1, DNA directed polymerase | |
| Synonyms | FLH21957|HEL-S-31|HGK|MEKKK4|NIK | AIBP80|REV1L | |
| Cytomap | 2q11.2 | 2q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase- | DNA repair protein REV1REV1 homologREV1, polymerase (DNA directed)REV1- likealpha integrin-binding protein 80rev1-like terminal deoxycytidyl transferase | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O95819 | Q9UBZ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000425019, ENST00000324219, ENST00000350198, ENST00000302217, ENST00000413150, ENST00000347699, ENST00000456652, ENST00000350878, ENST00000498066, | ENST00000393445, ENST00000258428, ENST00000465835, | |
| Fusion gene scores | * DoF score | 11 X 7 X 8=616 | 2 X 2 X 2=8 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MAP4K4 [Title/Abstract] AND REV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K4 | GO:0006468 | protein phosphorylation | 9890973 |
| Hgene | MAP4K4 | GO:0035556 | intracellular signal transduction | 9890973 |
| Hgene | MAP4K4 | GO:0046328 | regulation of JNK cascade | 14966141 |
| Tgene | REV1 | GO:0009411 | response to UV | 11485998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-PG-A914-01A | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000425019 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000425019 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000425019 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000324219 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000324219 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000324219 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000350198 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000350198 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000350198 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000302217 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000302217 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000302217 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000413150 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000413150 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000413150 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000347699 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000347699 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000347699 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000456652 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000456652 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000456652 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000350878 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| Frame-shift | ENST00000350878 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| 5CDS-5UTR | ENST00000350878 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| intron-3CDS | ENST00000498066 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| intron-3CDS | ENST00000498066 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
| intron-5UTR | ENST00000498066 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
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FusionProtFeatures for MAP4K4_REV1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K4 | REV1 |