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Fusion gene ID: 20841 |
FusionGeneSummary for MAP3K13_LIPH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP3K13_LIPH | Fusion gene ID: 20841 | Hgene | Tgene | Gene symbol | MAP3K13 | LIPH | Gene ID | 9175 | 200879 |
| Gene name | mitogen-activated protein kinase kinase kinase 13 | lipase H | |
| Synonyms | LZK|MEKK13|MLK | AH|ARWH2|HYPT7|LAH2|LPDLR|PLA1B|mPA-PLA1 | |
| Cytomap | 3q27.2 | 3q27.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase | lipase member HLPD lipase-related proteinlipase, member HmPA-PLA1 alphamembrane-associated phosphatidic acid-selective phospholipase A1-alphamembrane-bound phosphatidic acid-selective phospholipase A1phospholipase A(1)phospholipase A1 member B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43283 | Q8WWY8 | |
| Ensembl transtripts involved in fusion gene | ENST00000446828, ENST00000424227, ENST00000443863, ENST00000535426, ENST00000265026, ENST00000448876, ENST00000454237, ENST00000438798, | ENST00000296252, ENST00000424591, | |
| Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 6 X 6 X 5=180 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAP3K13 [Title/Abstract] AND LIPH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP3K13 | GO:0000186 | activation of MAPKK activity | 11726277 |
| Hgene | MAP3K13 | GO:0006468 | protein phosphorylation | 9353328|11726277 |
| Hgene | MAP3K13 | GO:0007254 | JNK cascade | 9353328|11726277 |
| Hgene | MAP3K13 | GO:0046777 | protein autophosphorylation | 9353328 |
| Hgene | MAP3K13 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12492477 |
| Tgene | LIPH | GO:0016042 | lipid catabolic process | 12963729 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-44-2656-01A | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000446828 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| 5CDS-intron | ENST00000446828 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| Frame-shift | ENST00000424227 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| 5CDS-intron | ENST00000424227 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| Frame-shift | ENST00000443863 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| 5CDS-intron | ENST00000443863 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| Frame-shift | ENST00000535426 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| 5CDS-intron | ENST00000535426 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| Frame-shift | ENST00000265026 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| 5CDS-intron | ENST00000265026 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| intron-3CDS | ENST00000448876 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| intron-intron | ENST00000448876 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| intron-3CDS | ENST00000454237 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| intron-intron | ENST00000454237 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| intron-3CDS | ENST00000438798 | ENST00000296252 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
| intron-intron | ENST00000438798 | ENST00000424591 | MAP3K13 | chr3 | 185183593 | + | LIPH | chr3 | 185270401 | - |
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FusionProtFeatures for MAP3K13_LIPH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K13 | LIPH |