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Fusion gene ID: 20768 |
FusionGeneSummary for MAN2C1_PTPN9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAN2C1_PTPN9 | Fusion gene ID: 20768 | Hgene | Tgene | Gene symbol | MAN2C1 | PTPN9 | Gene ID | 4123 | 5780 |
| Gene name | mannosidase alpha class 2C member 1 | protein tyrosine phosphatase, non-receptor type 9 | |
| Synonyms | MAN6A8|MANA|MANA1 | MEG2|PTPMEG2 | |
| Cytomap | 15q24.2 | 15q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-mannosidase 2C1alpha mannosidase 6A8Balpha-D-mannoside mannohydrolasemannosidase, alpha 6A8mannosidase, alpha A, cytoplasmictesticular tissue protein Li 115 | tyrosine-protein phosphatase non-receptor type 9PTPase-MEG2protein-tyrosine phosphatase MEG2 | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | Q9NTJ4 | P43378 | |
| Ensembl transtripts involved in fusion gene | ENST00000569482, ENST00000565683, ENST00000563622, ENST00000267978, ENST00000563539, | ENST00000306726, ENST00000564970, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 3 X 3 X 3=27 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAN2C1 [Title/Abstract] AND PTPN9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPN9 | GO:0010977 | negative regulation of neuron projection development | 27655914 |
| Tgene | PTPN9 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27655914 |
| Tgene | PTPN9 | GO:1903078 | positive regulation of protein localization to plasma membrane | 27655914 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-4Z-AA7Q-01A | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000569482 | ENST00000306726 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| 5CDS-intron | ENST00000569482 | ENST00000564970 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| Frame-shift | ENST00000565683 | ENST00000306726 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| 5CDS-intron | ENST00000565683 | ENST00000564970 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| Frame-shift | ENST00000563622 | ENST00000306726 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| 5CDS-intron | ENST00000563622 | ENST00000564970 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| Frame-shift | ENST00000267978 | ENST00000306726 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| 5CDS-intron | ENST00000267978 | ENST00000564970 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| 5UTR-3CDS | ENST00000563539 | ENST00000306726 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
| 5UTR-intron | ENST00000563539 | ENST00000564970 | MAN2C1 | chr15 | 75658863 | - | PTPN9 | chr15 | 75772255 | - |
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FusionProtFeatures for MAN2C1_PTPN9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAN2C1 | PTPN9 |