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Fusion gene ID: 20762 |
FusionGeneSummary for MAN2B2_TACC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAN2B2_TACC3 | Fusion gene ID: 20762 | Hgene | Tgene | Gene symbol | MAN2B2 | TACC3 | Gene ID | 23324 | 10460 |
| Gene name | mannosidase alpha class 2B member 2 | transforming acidic coiled-coil containing protein 3 | |
| Synonyms | - | ERIC-1|ERIC1 | |
| Cytomap | 4p16.1 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | epididymis-specific alpha-mannosidasecore-specific lysosomal alpha-1,6-Mannosidase | transforming acidic coiled-coil-containing protein 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y2E5 | Q9Y6A5 | |
| Ensembl transtripts involved in fusion gene | ENST00000285599, ENST00000504248, ENST00000504960, | ENST00000313288, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 10 X 13=780 |
| # samples | 2 | 42 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(42/780*10)=-0.893084796083488 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAN2B2 [Title/Abstract] AND TACC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-A3IS-01A | MAN2B2 | chr4 | 6580225 | + | TACC3 | chr4 | 1737458 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000285599 | ENST00000313288 | MAN2B2 | chr4 | 6580225 | + | TACC3 | chr4 | 1737458 | + |
| Frame-shift | ENST00000504248 | ENST00000313288 | MAN2B2 | chr4 | 6580225 | + | TACC3 | chr4 | 1737458 | + |
| intron-3CDS | ENST00000504960 | ENST00000313288 | MAN2B2 | chr4 | 6580225 | + | TACC3 | chr4 | 1737458 | + |
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FusionProtFeatures for MAN2B2_TACC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAN2B2 | TACC3 |