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Fusion gene ID: 20745 |
FusionGeneSummary for MAN1A2_VANGL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAN1A2_VANGL1 | Fusion gene ID: 20745 | Hgene | Tgene | Gene symbol | MAN1A2 | VANGL1 | Gene ID | 10905 | 81839 |
| Gene name | mannosidase alpha class 1A member 2 | VANGL planar cell polarity protein 1 | |
| Synonyms | MAN1B | KITENIN|LPP2|STB2|STBM2 | |
| Cytomap | 1p12 | 1p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IB | vang-like protein 1KAI1 C-terminal interacting tetraspaninloop-tail protein 2 homologstrabismus 2van Gogh-like protein 1vang-like 1 (van gogh, Drosophila) | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O60476 | Q8TAA9 | |
| Ensembl transtripts involved in fusion gene | ENST00000356554, ENST00000482811, | ENST00000355485, ENST00000369510, ENST00000310260, ENST00000369509, ENST00000474344, | |
| Fusion gene scores | * DoF score | 11 X 12 X 6=792 | 6 X 5 X 4=120 |
| # samples | 19 | 6 | |
| ** MAII score | log2(19/792*10)=-2.05950101174866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAN1A2 [Title/Abstract] AND VANGL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A0A6-01A | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000356554 | ENST00000355485 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| In-frame | ENST00000356554 | ENST00000369510 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| In-frame | ENST00000356554 | ENST00000310260 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| In-frame | ENST00000356554 | ENST00000369509 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| 5CDS-3UTR | ENST00000356554 | ENST00000474344 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| intron-3CDS | ENST00000482811 | ENST00000355485 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| intron-3CDS | ENST00000482811 | ENST00000369510 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| intron-3CDS | ENST00000482811 | ENST00000310260 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| intron-3CDS | ENST00000482811 | ENST00000369509 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
| intron-3UTR | ENST00000482811 | ENST00000474344 | MAN1A2 | chr1 | 117984947 | + | VANGL1 | chr1 | 116224985 | + |
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FusionProtFeatures for MAN1A2_VANGL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAN1A2 | VANGL1 |